Sri Lankan cricket team in South Africa in 2000–01

The Sri Lankan cricket team toured South Africa during the 2000–01 season, playing three Tests and six one-day internationals.

Sri Lanka was led by Sanath Jayasuriya while South Africa was led by Shaun Pollock. The tour began with a Test series consisting of three matches. South Africa won two Test matches, winning the series 2–0, with one Test drawn. At the end of the series, Gary Kirsten of South Africa emerged as the top run-scorer with 266 runs, with an average of 88.66. Shaun Pollock and Muttiah Muralitharan finished the series as top wicket-takers capturing 13 and 12 wickets respectively. Pollock was named "man of the series".