Staples Hollow

Staples Hollow is a valley in Ste. Genevieve County in the U.S. state of Missouri. The upper reaches of the valley lie just east of U.S. Route 61 north of Bloomsdale at 38.04139°N, -90.21222°W and the valley stream flows northeast to enter the Mississippi River floodplain at Clement where it joins Establishment Creek at 38.05778°N, -90.16639°W.

Staples Hollow has the name of the Staples family of settlers.