Substance

Substance may refer to:
 * Matter, anything that has mass and takes up space

Chemistry

 * Chemical substance, a material with a definite chemical composition
 * Drug, a chemical agent affecting an organism

Music

 * Substance (Blank & Jones album), 2002
 * Substance (Joy Division album), 1988
 * Substance 1987, a New Order album
 * "Substance", a song by Haste the Day on the album That They May Know You
 * "Substance" (song), a 2022 song by Demi Lovato

Other media

 * SubStance, an interdisciplinary journal on literature published by the University of Wisconsin Press
 * Metal Gear Solid 2: Substance, an update of the video game Metal Gear Solid 2: Sons of Liberty

Religion and philosophy

 * Dravya, a term used in Jainism to refer a substance
 * Ousia, term for substance in ancient Greek philosophy and Christian theology
 * Substance theory, an ontological theory positing that a substance is distinct from its properties