Sulfamation

In organic chemistry sulfamation is the installation of either of two related functional groups, sulfamic acid (R2NSO3H) and sulfamate (R2NSO3−). Typical methods entail reaction of primary amines with sources of sulfur trioxide such as pyridine-sulfur trioxide:
 * RNH2 +  SO3  →  RNHSO3H

Sulfamation can also be effected by treating the amine with the sulfate ester of catechol (C6H4O2SO2).