Sulfotransferase

In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group (R\sSO3-) from a donor molecule to an acceptor alcohol (R\sOH) or amine (R\sNH2). The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R\sOSO3-):



whereas an amine leads to a sulfamate (R\sNH\sSO3-):



Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.



Examples
The following are examples of sulfotransferases:


 * carbohydrate sulfotransferase: CHST1, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, CHST9, CHST10, CHST11, CHST12, CHST13, CHST14
 * galactose-3-O-sulfotransferase: GAL3ST1, GAL3ST2, GAL3ST3, GAL3ST4
 * heparan sulfate 2-O-sulfotransferase: HS2ST1
 * heparan sulfate 3-O-sulfotransferase: HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST4, HS3ST5, HS3ST6
 * heparan sulfate 6-O-sulfotransferase: HS6ST1, HS6ST2, HS6ST3
 * N-deacetylase/N-sulfotransferase: NDST1, NDST2, NDST3, NDST4
 * tyrosylprotein sulfotransferase: TPST1, TPST2
 * uronyl-2-sulfotransferase
 * Estrone sulfotransferase
 * Chondroitin 4-sulfotransferase
 * other: SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1B1, SULT1C2, SULT1C3, SULT1C4, SULT1D1P, SULT1E1, SULT2A1, SULT2B1, SULT4A1, SULT6B1