Swimming at the 1999 Pan American Games – Women's 4 × 100 metre freestyle relay

The women's 4 × 100 metre freestyle relay competition of the swimming events at the 1999 Pan American Games took place on August 4 at the Pan Am Pool. The last Pan American Games champion was the United States.

This race consisted of eight lengths of the pool. Each of the four swimmers completed two lengths of the pool. The first swimmer had to touch the wall before the second could leave the starting block.

Results
All times are in minutes and seconds.

Final
The final was held on August 4.