Swimming at the 1999 Pan American Games – Women's 4 × 100 metre medley relay

The women's 4 × 100 metre medley relay competition of the swimming events at the 1999 Pan American Games took place on August 6 at the Pan Am Pool. The last Pan American Games champion was the United States.

Results
All times are in minutes and seconds.

Final
The final was held on August 6.