Swimming at the 2006 Central American and Caribbean Games – Men's 4x100 metre freestyle relay

The men's 4 × 100 m Freestyle Relay event at the 2006 Central American and Caribbean Games occurred on Wednesday, July 19, 2006, at the S.U. Pedro de Heredia Aquatic Complex in Cartagena, Colombia.

Only 8 relays were entered in the event, and consequently, it was only swum once (in finals).

Records at the time of the event were:
 * World Record: 3:13.17, South Africa (Schoeman, Ferns, Townsend, Neethling), Athens, Greece, August 15, 2004.
 * Games Record: 3:23.49, 🇻🇪 Venezuela (Quevedo, Paez, Rojas, Sánchez), 1998 Games in Maracaibo (Aug.18.1998).