Swimming at the 2006 Central American and Caribbean Games – Men's 4x100 metre medley relay

The men's 4 × 100 m Medley Relay event at the 2006 Central American and Caribbean Games occurred on Saturday, July 22, 2006 at the S.U. Pedro de Heredia Aquatic Complex in Cartagena, Colombia.

Only 8 relays were entered in the event, and consequently, it was only swum once (in finals).

Records at the time of the event were:
 * World Record: 3:30.68, 🇺🇸 USA (Peirsol, Hansen, Crocker, Lezak), Athens, Greece, August 21, 2004.
 * Games Record: 3:44.61, 🇨🇺 Cuba (Falcón, González, Garcia, Hernandez), 1998 Games in Maracaibo (Aug.14.1998).