Swimming at the 2006 Central American and Caribbean Games – Women's 400 metre individual medley

The Women's 400 m Individual Medley event at the 2006 Central American and Caribbean Games occurred on Monday, July 17, 2006, at the S.U. Pedro de Heredia Aquatic Complex in Cartagena, Colombia.

Records at the time of the event were:
 * World Record: 4:33.59, Yana Klochkova (Ukraine), Sydney, Australia, September 16, 2000.
 * Games Record: 4:52.42, Carolyn Adel (Suriname), 1998 Games in Maracaibo (August.9.1998).