Swimming at the 2006 Central American and Caribbean Games – Women's 4x100 metre freestyle relay

The women's 4 × 100 m Freestyle Relay at the 2006 Central American and Caribbean Games occurred on Wednesday, July 19, 2006, at the S.U. Pedro de Heredia Aquatic Complex in Cartagena, Colombia.

Only 7 relays were entered in the event, and consequently, it was only swum once (in finals).

Records at the time of the event were:
 * World Record: 3:35.94, 🇦🇺 Australia (Mills, Lenton, Thomas, Henry), Athens, Greece, August 14, 2004.
 * Games Record: 3:57.55, 🇻🇪 Venezuela (Vilar, Lopes, Aponte, Semeco), 2002 Games in San Salvador (Nov.26.2002).