Swimming at the 2006 Central American and Caribbean Games – Women's 4x100 metre medley relay

The Women's 4x100m Medley Relay at the 2006 Central American and Caribbean Games occurred on July 21, 2006 at the S.U. Pedro de Heredia Aquatic Complex in Cartagena, Colombia.

Only 6 relays were entered in the event, and consequently, it was only swum once (in finals).

Records at the time of the event were:
 * World Record: 3:57.32, 🇦🇺 Australia (Rooney, Jones, Thomas, Henry), Athens, Greece, August 21, 2004.
 * Games Record: 4:23.42, 🇲🇽 Mexico (Marmolejo, Maristany, España, Lopez), 2002 Games in San Salvador (Nov.28.2002).