Swimming at the 2023 Pan American Games – Women's 4 × 100 metre medley relay

The women's 4 × 100 metre medley relay competition of the swimming events at the 2023 Pan American Games were held on October 25, 2023, at the Aquatic Center in Santiago, Chile.

Records
Prior to this competition, the existing world and Pan American Games records were as follows:

Heats
The highest eight scores advance to the final.

Final
The final was held on October 25.