Syndecan-2

Syndecan-2 is a protein that in humans is encoded by the SDC2 gene.

Function
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

Interactions
SDC2 has been shown to interact with:
 * CASK,
 * Laminin, alpha 3, and
 * EZR