TADDOL

In organic chemistry, TADDOL is an acronym for. These compounds are easily accessed and are often used as chiral auxiliaries.

TADDOLs consist of a dioxolane ring substituted with two mutually groups. They are derived from d,l-tartaric acid, an inexpensive C2-symmetric molecule. Condensation of dimethyl ester of d,l-tartaric acid with acetone gives the acetonide, a particular kind of dioxalane. The ester groups are susceptible to reaction with aryl Grignard reagents, leading after hydrolysis to the diol.