TFE3

Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.

Function
TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991).[supplied by OMIM]

Interactions
TFE3 has been shown to interact with:
 * E2F3,
 * Microphthalmia-associated transcription factor, and
 * Mothers against decapentaplegic homolog 3

Translocations
A proportion of renal carcinomas (RCC) that occur in young patients are associated with translocations involving the TFE3 gene at chromosome Xp11.2 PRCC