TLE

TLE may stand for:

Arts and entertainment

 * The Living End, an Australian band formed in 1994
 * Star Trek: The Lost Era, a novel series in the Star Trek franchise
 * Lost Experience, a game based on the Lost television series

Medicine

 * Temporal lobe epilepsy, the most common form of focal seizure, originating in the temporal lobe of the brain

Science and technology

 * Kimber Custom TLE II, a model of the Kimber Custom handgun
 * Temporal light effects, wanted or unwanted effects caused by light modulations
 * Total lunar eclipse, an astronomical event
 * Transient luminous event, or upper-atmospheric lightning, a weather phenomenon
 * Two-line element set, a format for distributing orbital element data

Other uses

 * Technology and Livelihood Education, part of an educational curriculum in the Philippines
 * The London Economic, a left-wing digital newspaper based in the UK
 * The Last Elegy, a Brazilian esports team