TPF

TPF may refer to:
 * Tibial plateau fracture
 * Theodore Payne Foundation for Wild Flowers and Native Plants
 * Transaction Processing Facility, an operating system by IBM
 * Terrestrial Planet Finder, a proposed system of telescopes to detect extrasolar planets
 * The Pop Factory, a Welsh television program
 * The Perl Foundation, a non-profit organization
 * The Proud Family, a Disney Channel Original Series
 * Tapered-polymer-fiber, a type of laser
 * Docetaxel, Cisplatin, and fluorouracil, a chemotherapy regimen used in head and neck cancer
 * Tokyopop, a manga publishing company
 * Telangana Praja Front, a political party
 * Transports publics Fribourgeois, a public transport operator in the Swiss canton of Fribourg
 * Tribunal pénal fédéral, the Swiss Supreme Court for criminal matters
 * Peter O. Knight Airport, IATA airport code
 * Tooting Popular Front, a fictional revolutionary organisation in Citizen Smith
 * The Purse Forum, a popular online forum dedicated to the discussion of fashion and luxury goods
 * National Treatment Purchase Fund, the Irish healthcare programme
 * Tachi Palace Fights, an American Mixed Martial Arts promotion.
 * Transport Fever, a computer game
 * Tactical Patrol Force, slang term for riot control squad
 * Trade promotion forecasting