TRIB3

Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.

Function
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target.

Interactions
TRIB3 has been shown to interact with:
 * AKT1,
 * CSNK2B,
 * Fibronectin
 * MCM3AP,
 * RELA,
 * SIAH1, and
 * TIAF1.