TRNA (guanine26-N2)-dimethyltransferase

TRNA (guanine26-N2)-dimethyltransferase (, Trm1p, TRM1, tRNA (m22G26)dimethyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine26-N2)-dimethyltransferase. This enzyme catalyses the following chemical reaction


 * 2 S-adenosyl-L-methionine + guanine26 in tRNA $$\rightleftharpoons$$ 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA

The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.