Tabernanthine

Tabernanthine is an alkaloid found in Tabernanthe iboga.

It has been used in laboratory experiments to study how addiction affects the brain.

Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.

Pharmacology
It is kappa opioid agonist (Ki = 0.15 μM) and NMDA receptor (Ki = 10.5 μM) antagonist. Compared to ibogaine, it binds weakly to σ1 and σ2 receptor.