Talk:2′-Acetoxycocaine

acetylsalicylic acid
If the metabolites or the inherent structure of 2'-acetoxycocaine has any affinity to blood thinning properties due to its similarity to acetylsalicylic acid, this would be important to source and note within the article. Nagelfar (talk) 00:50, 14 November 2011 (UTC)

Quicker onset due to extra acetyl branch
Would 2'acetoxy-cocaine have more rapid onset due to the very branch substitution in the same way acetyl-morphine derivatives cross the blood-brain barrier quicker? Would this be verified with a citation of some sort if it is the case? 66.96.79.211 (talk) 01:49, 15 December 2012 (UTC)

Perhaps too, the cleavage of the 2'-acetoxy would be rapid and the effects would mostly be of the potency of cocaine, being a prodrug to such, thereafter? hopefully the initial greater NE affinity would not be too dangerous or could be easily augmented (perhaps a 2',4'-acetoxy, with the "4'-" lowing NET and greatening SERT affinity and balacing it out, while greatening onset speed even more?). Nagelfar (talk) 02:48, 24 January 2013 (UTC)

IUPAC name. Is the stereoisomerism correct?
It gives "(1R,2R,3S,5S)-Methyl 3-((2-acetoxybenzoyl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate" but if it were the same as cocaine in orientation wouldn't it instead be "methyl(1R,2R,3S,5S)-3-(2-acetoxybenzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate" or does this analog have a different specific orientation for some reason? Nagelfar (talk) 22:56, 27 February 2015 (UTC)