Talk:3,14-Diacetyloxymorphone

Esters
Almost the phenanthracene & morphinan opioids may be acetylated. It is inefficient to post every analogue. A table, like that in 'Opiates' by R. Lenz et all would cut down the number of pages vastly allowing a students to see the chiral centres which are not always included in Wiki. If it's for educational purposes, proper reference is required. — Preceding unsigned comment added by 81.99.74.135 (talk) 12:35, 23 March 2017 (UTC)

Potency
The estimation of potency of the 3,6,14-triacetoxy derivative does not look sound. While a 6-acetyloxy group is more potent than an 6-hydroxy, a 6-keto is MORE potent. In the references given in the papers discussing the 14-esters of codeinone (The analgesic properties of some 14-substituted derivatives of codeine and codeinone;J. Pharm. Pharmacol., 1964, 16, 174-182), the 6-acetyl derivatives were less potent than the parent 6 hydroxy compounds. Note that the 3 & 6-monoacetyl & 3,6-diacetyl esters of dihydromorphine are less potent than diamorphine & that thebacon is less potent than hydrocodone but with a longer duration. — Preceding unsigned comment added by 81.99.74.135 (talk) 20:00, 12 March 2019 (UTC)