Talk:4-Hydroxynonenal

Characterization of 4-hydroxy-2,3-trans-nonenal (4-HNE)
Dear Sir or Madam,

The article on 4-hydroxy-2,3-trans-nonenal (4-HNE) states that: ”The first characterization of 4-hydroxynonenal was reported by Esterbauer, et al. In 1991”, which is not entirely true. The first paper on 4-HNE (in English) by Prof. Esterbauer and colleagues dates back to 1980 (Benedetti, Comporti, Esterbauer, see below).

From 1986 on the research groups of Prof. J.F. Koster (Rotterdam) and Prof. H. Esterbauer (Graz) published several papers on the biochemistry and cell biology of 4-HNE (e.g. Possible involvement of the lipid-peroxidation product 4-hydroxynonenal in the formation of fluorescent chromolipids. Esterbauer H, Koller E, Slee RG, Koster JF. Biochem J. (1986) Oct 15;239(2):405-9. doi: 10.1042/bj2390405; Influence of cumene hydroperoxide and 4-hydroxynonenal on the glutathione metabolism during in vitro ageing of human skin fibroblasts. Poot M, Verkerk A, Koster JF, Esterbauer H, Jongkind JF. Eur J Biochem. (1987) Jan 15; 162(2):287-91. doi: 10.1111/j.1432-1033.1987.tb10598.x). Notably, 4-HNE inhibits proliferation of skin-derived and amniotic fluid-derived fibroblasts, yet it does not seem to account for cellular ageing in general (Disturbance of cell proliferation by two model compounds of lipid peroxidation contradicts causative role in proliferative senescence. Poot M, Esterbauer H, Rabinovitch PS, Hoehn H. J Cell Physiol. (1988) Dec;137(3):421-9. doi: 10.1002/jcp.1041370305).

I hope you may find these remarks helpful, and remain with best wishes,

Martin Poot, Ph.D., Dr.med.habil

martin_poot@hotmail.com

A Benedetti, M Comporti, H Esterbauer, Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids, Biochim Biophys Acta (1980) Nov 7;620(2):281-296. PMID: 6254573. DOI: 10.1016/0005-2760(80)90209-x.

Abstract During the NADPH-Fe induced peroxidation of liver microsomal lipids, products are formed which show various cytopathological effects including inhibition of microsomal glucose-6-phosphatase. The major cytotoxic substance has been isolated and identified as 4-hydroxy-2,3-trans-nonenal. The structure was ascertained by means of ultraviolet, infrared and mass spectrometry and high-pressure liquid chromatographic analysis. Moreover, 4-hydroxynonenal, prepared by chemical synthesis, was found to reproduce the biological effects brought about by the biogenic aldehyde. Preliminary investigations suggest that as compared to 4-hydroxynonenal very low amounts of other 4-hydroxyalkenals, namely 4-hydroxyoctenal, 4-hydroxydecenal and 4-hydroxyundecenal are also formed by actively peroxidizing liver microsomes. In the absence of NADPH-Fe liver microsomes produced only minute amounts of 4-hydroxyalkenals. The biochemical and biological effects of synthetic 4-hydroxyalkenals have been studied in great detail in the past. The results of these investigations together with the finding that 4-hydroxyalkenals, in particular 4-hydroxynonenal, are formed during NADPH-Fe stimulated peroxidation of liver microsomal lipids, may help to elucidate the mechanism by which lipid peroxidation causes deleterious effects on cells and cell constituents. 2A00:20:C018:5F06:FC58:8FAE:D345:869 (talk) 13:51, 14 October 2022 (UTC)
 * The topic has been the subject of thousands of papers and many reviews. I revised the references to the early work and an overview.  For topics that are so well developed, Wikipedia mainly seeks books and reviews not primary literature, except discoveries.  With that guideline in mind (WP:SECONDARY), you are encouraged to contribute to the article.--Smokefoot (talk) 17:23, 14 October 2022 (UTC)