Talk:A549 cell

Untitled
A549 cells share the same characteristics with the alveolar type II cells. This are type II pneumocytes crucial for lung homeostasis, and regeneration upon damage. For research purposes to unravel different molecular mechanisms leading to lung diseases, A549 cells serves as a good model to which translational research can be relied upon. Among other characteristics is their ability to secret phospholipids and also the surfactant proteins.

They could be squamous but there is a lot of debate going on as they should be cuboidal... —Preceding unsigned comment added by 145.118.110.19 (talk) 17:55, 4 April 2011 (UTC)

Why are these cells so preferred?

I'm no cell biologst, but I think its the avleolar cell's affinity for absorbing and excreting that makes it so popular. The fact that it is a flat, basal cell, suitable for easy viewing through microscopes, without having to change focus to view most of the cell. This is all guesswork..

Google results:

Development and application of adenoviral vectors for gene therapy of cancer WW Zhang - Cancer Gene Therapy, 1999 - nature.com ... The benefit of using A549 cells is mainly that the cells have a high level of sensitivity and permissibility to Ad infection and replication. ...

Article costs $30 dollars. I haven't searched profusion yet.

This is my first article! Thanks to everyone who raised it to a Higher Standard of Quality! <3

Adherent or suspension?
From the article: "The human alveolar epithelial cell line A549 may be anchored or suspended in a solution in vitro." So is this cell line adherent or suspension? Of course, any adherent cell line can be put into suspension, but under normal growth conditions, a cell line is one or the other. ATCC says adherent:  142.103.207.10 (talk) 22:36, 14 May 2008 (UTC)

Article Suggestions
This is a good start, but I think it would be super helpful if information such as cell characteristics and types of experiments/uses it has. The information above is a great place to start. It would also be a really good idea to link this page to the Immortalised Cell Line wiki page so readers can get a better understanding of what kind of cell this is.180Degrees (talk) 02:53, 1 February 2017 (UTC)

Adenovirus
I believe Adenovirus 5 is integrated, but I am not sure. I came to wikipedia to find out which adenovirus is integrated. Would it be possible to add this information specifically to the article? 2A02:8388:1641:5500:8207:8CE:DF2:AB90 (talk) 08:09, 3 December 2022 (UTC)