Talk:APICA (synthetic cannabinoid drug)

Naming scheme
It should be mentioned that the name "APICA" is an acronym of N-(1-Adamantyl)-1-Pentyl-1H-Indole-3-CarboxAmide. Enix150 (talk) 08:27, 29 October 2015 (UTC)

Ambiguous name
Hey guys, I just noticed that there is already another drug on Wikipedia going by the acronym APICA. This is possibly why the authors of the most recent study of this compound opted to rename it SDB-001. Should a similar name change be considered here, with other synonyms placed in parentheses? BaeyerDrewson (talk) 22:37, 3 April 2013 (UTC)

UK Legal Status
This is a class B drug covered by the blanket ban clause in Misuse of Drugs Act 1971 - paragraph 1(ca) of Part 2 of Schedule 2


 * (ca)any compound (not being a compound for the time being specified in sub-paragraph (c) above) structurally related to 1-pentyl-3-(1-naphthoyl)indole (JWH-018), in that the four sub-structures, that is to say the indole ring, the pentyl substituent, the methanone linking group and the naphthyl ring, are linked together in a similar manner, whether or not any of the sub-structures have been modified, and whether or not substituted in any of the linked sub-structures with a benzyl or phenyl group and whether or not such compound is further substituted to any extent with alkyl, alkenyl, alkoxy, halide, haloalkyl or cyano substituents and, where any of the sub-structures have been modified, the modifications of the sub-structures are limited to any of the following, that is to say—


 * (i)replacement of the indole ring with indane, indene, indazole, pyrrole, pyrazole, imidazole, benzimidazole, pyrrolo[2,3-b]pyridine, pyrrolo[3,2-c]pyridine or pyrazolo[3,4‑b]pyridine;


 * (ii)replacement of the pentyl substituent with alkyl, alkenyl, benzyl, cycloalkylmethyl, cycloalkylethyl, (N-methylpiperidin-2-yl)methyl, 2-(4-morpholinyl)ethyl or (tetrahydropyran-4-yl)methyl;


 * (iii)replacement of the methanone linking group with an ethanone, carboxamide, carboxylate, methylene bridge or methine group;


 * (iv)replacement of the 1-naphthyl ring with 2-naphthyl, phenyl, benzyl, adamantyl, cycloalkyl, cycloalkylmethyl, cycloalkylethyl, bicyclo[2.2.1]heptanyl, 1,2,3,4-tetrahydronaphthyl, quinolinyl, isoquinolinyl, 1-amino-1-oxopropan-2-yl, 1‑hydroxy-1-oxopropan-2-yl, piperidinyl, morpholinyl, pyrrolidinyl, tetrahydropyranyl or piperazinyl.

It is a modification of JWH-018 by the following changes:


 * No replacement of the indole ring
 * No replacement of pentyl
 * Replacement of the methanone linking group with carboxamide
 * Replacement of 1-napthyl with adamantyl

Testem (talk) 22:11, 18 October 2020 (UTC)