Talk:Acanthosis nigricans

Treatment
People with acanthosis nigricans should be screened for diabetes and cancer.

to screen a patient for diabetes or cancer or something else is not a direct treatment for a skin disease... rename this or move it in an other part of this page ?
 * This is more of a symptom than a disease. It's entirely appropriate to treat the underlying disorder rather than treating the symptom.  Gigs (talk) 23:47, 6 June 2008 (UT

Scientists have also found that having high insulin levels over long periods of time can increase the risk of the following conditions: obesity, cardiovascular problems, hypertension, increased cholesterol and triglycerides, in females high insulin levels may increase the risk of developing Polycystic Ovarian Syndrome that is characterized by amenorrhea (irregular menstrual cycles) and/or(?) hirsutism (extreme facial hair) severe acne and enlarged ovaries.

Merge

 * Oppose - I agree with Megapen (talk) that Acral Acanthotic Anomaly is a seperate issue and should not be part of this page. — Preceding unsigned comment added by 176.253.28.206 (talk) 09:45, 1 June 2015 (UTC)
 * Oppose - Acral Acanthotic Anomaly is separate and distinct. It is not associated with underlying disorders, as is acanthosis nigricans. Thus, it is important not to confuse the two entities. --Megapen (talk) 16:11, 22 February 2009 (UTC)
 * Strong oppose - Acral acanthotic anomaly and acanthosis nigricans are very different conditions. Also, I feel each type of acanthosis nigricans deserves its own article as each has its own etiology, incidence, treatment, etc. kilbad (talk) 17:49, 22 February 2009 (UTC)

Connection to EDS?
I know that acanthosis nigricans can be linked to certain types of Ehlers-Danlos Syndrome, but I'm having trouble finding a reliable source to cite it. It's not enough to go by personal experience, is it? 207.216.143.140 (talk) 05:04, 6 January 2013 (UTC)Anon

Proposed merge
Hello to all! I am proposing a merge from the following articles into this article:
 * Acanthosis nigricans associated with obesity, insulin-resistant states, and endocrinopathy
 * Acral acanthosis nigricans
 * Acanthosis nigricans associated with malignancy
 * Familial acanthosis nigricans

This is for the following reasons:
 * The main article would benefit significantly from having all this information in one place.
 * These articles are very short in length (1-2 sentences) and have not been edited significantly in 3-4 years.
 * This knowledge shouldn't be obscured from readers of this article by virtue of being isolated in an obscure article of 1-2 lines.
 * These topics may receive more attention by being mentioned in the main article.
 * The articles, if needs be, could be re-expanded at a later date.

Kind Regards, LT90001 (talk) 14:17, 9 August 2013 (UTC)
 * In the absence of objections, I have merged these articles. LT90001 (talk) 07:50, 23 August 2013 (UTC)

Melanocyte proliferation?
"The high insulin concentrations probably activate growth factor receptors (perhaps the IGF1 receptor) that drive the proliferation of keratinocytes and melanocytes." According to Weedon's Dermatopathology, the darkening appearance is largely due to acanthosis, rather than hyperpigmentation. Do we know for sure that melanocytes proliferate in this condition? Thanks. Epithelium (talk) 07:57, 13 August 2013 (UTC)

External links modified
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