Talk:Acetylcarnitine

Untitled
I don't quite understand the following phrase. Could it be clarified, or corrected? "The L-carnitine is cycled back into the mitochondria by transporting more acyl groups..." Briancady413 (talk) 19:16, 20 January 2010 (UTC)

"Valproate and Acetyl-l-carnitine Prevent Methamphetamine-Induced Behavioral Sensitization in Mice"
http://onlinelibrary.wiley.com/doi/10.1196/annals.1403.019/full ... Nagelfar (talk) 23:49, 14 February 2012 (UTC)

Health claims same as Carnitine?
The "Health claims" section seems to be just a poor copy of Carnitine.

Does Acetylcarnitine actually have any benefits that are specific to it (i.e. you get them from Acetylcarnitine but not from L-carnitine)?

If not then this article should just say that the health benefits are the same as carnitine, instead of having a poor copy. Gronky (talk) 03:28, 4 January 2013 (UTC)

Report of new research, April 7, 2013
I am not qualified to properly evaluate the applicability of the info from the following link to this article. Here's the link: Forbe's article linking carnitine to artherosclerosis Can someone please have a look? Thank you, Peatbog (talk) 22:31, 7 April 2013 (UTC)

Peyronie's disease
I have removed the content below from the article space:

ALCAR has been shown to be more effective than tamoxifen in improving the curvature and reducing the pain and plaque sizes for men who sought treatment for their Peyronie's disease early and having low curvature deformities.


 * Discussion
 * The face the editor has left their Google Books search text ("Carnitine improves libido") in the text does not give confidence. More generally, is this reliably sourced? Alexbrn talk 07:20, 31 March 2014 (UTC)

Link to - and possible treatment of? - depression
Can someone link to this new study please? And a new systematic review and meta-analysis:
 * Acetyl-l-carnitine deficiency in patients with major depressive disorder
 * Study links depression to low blood levels of acetyl-L-carnitine
 * Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis.

Possible copyright problem
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2018 meta-analysis on depression

 * Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis (2018) - is this a good-quality meta-analysis worthy of inclusion into the article, or is it low-quality? --- C opper K ettle  13:47, 23 May 2020 (UTC)

Acyl vs Acetyl
I find the alternating use of Acyl and Acetyl confusing. While Acyl may be correct in modern usage, it is non-IUPAC, unfamiliar to me (a graduate chemist), and appears to be a typo to one not accustomed to the term. The article title is Acetylcarnitine, the compound is given in the header as 'Acetyl-L-carnitine'—why not stay with 'acetyl' for simplicity and clarity's sake? Add your comments, agree or disagree....
 * It gets worse: there's a dictionary out there, apparently authoritative, THE AMERICAN HERITAGE® SCIENCE DICTIONARY, cited in dictionary.com no less, which defines "acyl" as "...containing the group RCO, where R is a halogen." [emphasis mine]. That's not a definition of "acyl", that's an acyl halide, a completely different animal. That could really confuse someone who happened to look up the term there! I maintain that the use of "acyl" in the article is confusing to the lay reader & should be replaced. It is a 19th century German coinage, of limited English use; if you want to get technical, say "alkanoyl" or "alkyl carbonyl" with some mention of what the alkyl group can be. I am reluctant to do the edit myself as I am unclear as to how general "acyl" is intended to be here: is it just acetyl without the —OH, or are there other —RC=O groups implied, and if so, what Rs? I wouldn't touch this without a bunch of literature research, so I hope the original editor stops by, or someone familiar with the biochemistry of this class of compound. --D Anthony Patriarche (talk) 21:00, 5 May 2022 (UTC)