Talk:Acetylcholine receptor

Contradiction to textbooks and article about muscarinic acetylcholine receptors
The paragraph about the mAChR claims that "The alpha subunit of the G-protein activates guanylate cyclase (inhibiting the effects of intracellular cAMP) [...]". This is in contradiction to basically all textbooks and the common understanding of GPCRs. Gs- or Gi-coupled GPCRs act on adenylate cyclase to increase or inhibit cAMP-production, respectively. Direct activation of guanylate cyclases should not be possible, given that GCs are ligand-activated enzymes (directly binding extracellular peptides or NO). The article about the muscarinic receptors does not even mention cGMP. If this statement was actually true (which would come as a surprise to me), it would need a citation. — Preceding unsigned comment added by MosesMaWo (talk • contribs) 06:04, 17 May 2023 (UTC)

Untitled
I believe nicotinic receptor slows the heart rate when ach binds to the receptor and it contradicts your description about acetylcholine receptor. Please check and make corrections if neccessary.

Thank you,

yoko onishi

Hi Yoko - what is the specific contradiction? Acetylcholine receptors can be both excitatory or inhibitory depending on the subtype.

Someone should probably add a passing mention of the role these receptors play in the autonomic nervous system. 128.42.167.200 22:28, 20 February 2006 (UTC)

Hi Yoko and other :-)

I would sincerely like some more information on this as there is definitely a role for lower arousal due to upregulation of cholinergic receptors in offspring of mothers who smoke in pregnancy. I'm a novice at all of this so would appreciate any input in this regard. I believe that the balance between the sympathetic and parasympathetic branches of the ANS are altered by maternal smoking and have subsequent effects on behaviour when the upregulation is not 'satisfied' by continued nicotine/cigarette smoke. There is also a role for carbon monoxide's effects on norepinephrine. Any comments or help much appreciated. Alison

What kind of analogy is "staves around a barrel"? A stave (or "staff") to me is the 5 horizontal lines upon which you write notes in musical notation. An analogy is supposed to be provided to make it easier to comprehend the subject matter, not to cause the reader to have to research the terms used in the analogy and then come away still not understanding the intent of the writer.

I've been studying this subject out of my spare time, and I was wondering how to pronounce "acetylcholine". Does anyone know how? 98.247.153.182 (talk) 11:22, 24 February 2009 (UTC) A twelve year-old in search of knowledge --24.233.100.158 13:20, 12 August 2007 (UTC)

Minor change
The picture was changed to the one used in acetylcholine because the old does not meet the criteria for chemical formulas.

-- Panoramix303 18:07, 8 November 2007 (UTC)

Hei! You say in article: "The cytoplasm side of the nAChR receptor has rings of high negative charge that determine the specific cation specificity of the receptor and remove the hydration shell often formed by ions in aqueous solution. In the intermediate region of the receptor, within the pore lumen, valine and leucine residues (Val 255 and Leu 251) define a hydrophobic region which the dehydrated ion must pass through.[2]"

But the ions do not lose the hydration because there is no place that atracts their water and the pore widens enough so the ion can pass along with the binded water. The article (2) you refer to also says so and not what you wrote. —Preceding unsigned comment added by 90.227.59.93 (talk) 10:51, 20 October 2009 (UTC)

I added information under Role in Health and Disease about the effects of mutations on AChRs and the role they play in Congenital myasthenic syndrome. Jaforward13 (talk) 20:01, 24 April 2013 (UTC)

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Table legend
The symbols '-' and '+', which probably denote agonist/antagonist action in the table, need to be explained in a legend. vkehayas 15:17, 26 May 2017 (UTC) — Preceding unsigned comment added by Vkehayas (talk • contribs)

Wonky paragraph
I feel like in this paragraph, the information bookending the sentence on Myasthenia Gravis is confusing, "Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at the neuromuscular junction is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine." Because the first sentence is about nicotinic receptors and the last is about muscarinic receptors, but there is no mention or clarification of how either of these relate to Myasthenia Gravis. I was trying to further understand the disease, but this section led to more confusion. Mangofirst (talk) 22:05, 3 February 2019 (UTC)