Talk:Afoxolaner

Elimination half-life is NOT 14 hours
Wikipedia now says:

Elimination half-life: 14 hours

This can't be right, not even close. The drug is given every 30 days to dogs.

For toxicology what is important is elimination half-life in BLOOD. This can't be 14 hours, because afoxolaner binds tightly to plasma proteins. How are plasma proteins eliminated and what is half-life of plasma proteins?

For efficacy against Ticks what is important is elimnation half-life in SKIN? Which is likely longer than in blood.

91.159.188.106 (talk) 13:00, 15 March 2024 (UTC)

Legal status is incorrect, as FrontPro is OTC drug in Europe
Wikipedia claims:

Legal status CA: ℞-only US: ℞-only EU: Rx-only OTC (RU)

With so many errors in this Wikipedia article, can we trust even other information on this page?

For example Frontpro 136mg is over-the-counter drug for 25-50kg dogs in European Union. No precription is required, sold at pharmacy for example in Finland.

Afoxolaner was a prescription-only drug and prescription-only brands of this drug still exist.

91.159.188.106 (talk) 12:58, 15 March 2024 (UTC)

Neurological side effect for Dogs is a major concern
Neurological side effect for Dogs is much more common than vet drug manufacturers claim in product labels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738705/ 2020 Nov.

A veterinarian and pet owner survey (Project Jake) examined the use and safety of isoxazoline parasiticides given to dogs.

58% (1594) had been treated with some parasiticide for flea control, and of those that received a parasiticide, the majority, or 83% (1,325), received an isooxazoline. When any flea treatment was given, AE were reported for 66.6% of respondents, with no apparent AE noted for 36.1%.

Survey responders did not indicate the Recovery Status from neurological effects. However, several isolated reports (private communications with the authors of which 3 are veterinarians have indicated extended long‐term neurologic signs with InComplete amelioration).

With respect to pet age, serious AE showed death reported in about 60% of dogs older than 5 years with seizures in more than 50% of dogs older than 5 years.

The most serious AE as stated in the EMA cumulative reports were observed at 0–24 hr after the first dose, and then again after the second and third doses.

91.159.188.106 (talk) 15:51, 15 March 2024 (UTC)