Talk:Aldosterone

Untitled
i have too much


 * Conn's syndrome? JFW | T@lk  02:24, 10 Mar 2005 (UTC)

Renin
Umm, Renin? I gather that the hypothalmus produces Renin which converts angiotensin I to  angiotensin II causing the adrenal cortex to release Aldosterone. I came here to confirm that, though, and there's nothing here on that.


 * Renin is produced by the kidneys and converts angiotensinogen to angiotensin I. See renin-angiotensin system. --David Iberri 22:12, 16 November 2005 (UTC)

Where is reference to aldosterone and cytokines in hyperthermia? Not in PubMed jftait 15Dec05

Renin is produced in the juxtaglomerular cells of the kidney, usually the juxtaglomerular cells are stimulated by prostacyclin which is released from the macula densa if there is a decrease in urine sodium

Removed the following paragraph from article
"about 75% of the daily production is secreted between 04:00 am and 10:00 am each day" That is just false. It depends on when you wake up..

Aldosterone correction
In aldosterone section 'human (corticosterone in rodents)' is not correct. Aldosterone is the dominant mineralocorticoid in all mammals studied. Corticosterone is actually the dominant glucocorticoid in rodents as cortisol the dominant glucocorticoid in humans is not produced in rodents (no 17 hydoxylase). Corticosterone, although slightly more potent than cortisol, is actually quite weak in mineralocorticoid activity. Corticosterone is probably more than 1000 time less potent (per equivalent mass) than aldosterone which is definitely secreted in appreciable amounts by rodents. This sentence gives the wrong iumpression and should be corrected. 'mammals' instead of 'human (corticosterone in rodents' should be sufficient.

James Tait —The preceding unsigned comment was added by 80.189.140.245 (talk) 19:47, 9 December 2006 (UTC).

Principal Cells
Are not principle cells in the collecting duct? The article implies that it is in the distal tubule. --Shishidontknwshit


 * Both. —Preceding unsigned comment added by 129.176.151.10 (talk) 15:21, 22 June 2009 (UTC)

for point 4)...aldosterone stimulating K intake....doesnt aldosterone stimulate K+ secretion from principal cells...? —Preceding unsigned comment added by 68.112.165.240 (talk) 21:45, 5 December 2010 (UTC)

Question
increased aldosterone leads to : a) hypernatremia b hypokalemia c hypertension d  all of the above

Answer: d (Aldosteron activates Na/K exchanger (natrium in blood high, in urine kalium high). Increased blood natrium leads to hypertension — Preceding unsigned comment added by 130.60.206.75 (talk) 14:03, 28 June 2012 (UTC)

Please improve the clarity of this section Miscellaneous regulators

 * Miscellaneous regulators
 * The role of sympathetic nerves
 * The aldosterone production is also affected to one extent or another by nervous control, which integrates the inverse of carotid artery pressure,[14] pain, posture,[18] and probably emotion (anxiety, fear, and hostility) [21] (including surgical stress).[22] Anxiety increases aldosterone,[21] which must have evolved because of the time delay involved in migration of aldosterone into the cell nucleus.[23] Thus, there is an advantage to an animal's anticipating a future need from interaction with a predator, since too high a serum content of potassium has very adverse effects on nervous transmission.

Section needs re-write for clarity... first sentence "INTEGRATES"?

Maybe get new info from Goodfriend, T.L., 2006. Aldosterone--a hormone of cardiovascular adaptation and maladaptation. Journal of Clinical Hypertension (Greenwich, Conn.), 8(2), pp.133-139.

REST OF INFO IS PROBABLY FOUND IN REF 23 BUT CITATION IS NOT COMPLETE Sharp GUG Leaf A 1966 in; Recent Progress in Hormone Research.(Pincus G, ed. Maybe SHARP, G. U. G. LEAF, A. (1966). In: Recent Progress in Hormone Research (Pincus, G., ed.) pp. 431-472. New York: Academic Press

Maybe this is better? Tan, L.-B., Schlosshan, D. & Barker, D., 2004. Fiftieth anniversary of aldosterone: from discovery to cardiovascular therapy. International Journal of Cardiology, 96(3), pp.321-333.

or this review? Ambroisine, M. et al., 2004. Aldosterone and anti-aldosterone effects in cardiovascular diseases and diabetic nephropathy. Diabetes & Metabolism, 30(4), pp.311-318.--YakbutterT (talk) 22:46, 19 October 2011 (UTC)

Assessment comment
Substituted at 07:08, 29 April 2016 (UTC)