Talk:Alpha-1 antitrypsin

Untitled
Vivek Kumar Gupta has done lot of research on AAT and has come up with very interesting findings on AAT and other serpins and their interactions with GAGS.

It'd be great to see some more precise information on the genetics behind A1AT deficiency, ie whether it's recessive or co-dominant etc. (I haven't been able to ascertain this from the articles I've read). (Montgomery.tg (talk) 15:06, 13 November 2008 (UTC))

Name
I believe the proper name is "Alpha-1 Antitrypsin", with the hyphen moved between Alpha and 1. Is there any reason for the change? Also note that the associated disease, A1AD has its name changed too.

--superweapons (talk) 02:01, 30 January 2009 (UTC)

what is it bound to in the plasma
what is it bound to in the plasma? —Preceding unsigned comment added by 70.225.107.228 (talk) 14:28, 28 July 2009 (UTC)

COI edits
made a series of edits that introduced a number of primary sources including several papers with Bristow CL as author. My concerns are first of all that the editor has a conflict of interest, and that the sources do not meet WP:MEDRS. Happy to discuss further. JFW &#124; T@lk  20:20, 23 April 2019 (UTC)


 * You are correct to notice that my edits have a personal interest. However, your concern regarding conflict of interest should be mitigated by the fact that the references added are from top tier peer-reviewed scientific journals which had been previously overlooked in the Wikipedia entry and, as a result, the page provided less than accurate information.I thank you for your vigilance and welcome any suggestions to rectify your hesitations. Clbristow (talk) 22:41, 23 April 2019 (UTC)

The correct response, as far as I am concerned, would not have been to revert my edit. You did not address my added concerns that the papers you have quoted do not meet the reference standards from WP:MEDRS. I would strongly encourage you to cite high-quality secondary sources (generally reviews or textbooks). Whether an article was published in a top tier journal is not actually the main determinant of suitability. Let me know if you require assistance. JFW &#124; T@lk  20:11, 30 April 2019 (UTC)


 * Got it. Thank you. This is my first time making corrections and using Talk. I didn't understand such things as "MEDRS." I will make new edits and use review articles as secondary sources.Clbristow (talk) 14:28, 3 May 2019 (UTC)

Most of the content you are adding still cites primary research studies. I also don't think the information you provide should necessarily be in the introduction of the article. Sorry for reverting to jargon (e.g. MEDRS) but this is the standard we apply to all biomedical Wikipedia articles. JFW &#124; T@lk  20:31, 5 May 2019 (UTC)

Sorry I was being unfair. Only one reference was primary (JCI 1993, 10.1172/JCI116797) and I have taken the liberty to prune it as there was another reference for the content. Please do consider whether this information is better captured in the article body - normally we don't say things in the introduction that are not matched with more detailed content further down in the article. JFW &#124; T@lk  20:34, 5 May 2019 (UTC)

Great teamwork. The article better represents current knowledge, and I very much appreciate your assistance in educating me about making edits and helping me update. Time allowing, I will review the article sections soon for repositioning information to other sections based on your recommendations. Clbristow (talk) 18:32, 6 May 2019 (UTC)


 * Fabulous. Thanks for your patience - your ongoing contributions are appreciated and valued. JFW &#124; T@lk  11:03, 7 May 2019 (UTC)

Epigenetics
The following was added:


 * Epigenetics

Recent findings indicate that A1AT may be epigenetically regulated in the white blood cells. Indeed, the SERPINA1 gene promoter region has been found to be differentially methylated in peripheral blood mononuclear cells of healthy subjects in association with changes in circulating A1AT levels. In details, promoter methylation and low A1AT serum levels have been reported in different cohorts of healthy subjects, including blood donors and pregnant women at early pregnancy, while a reduced promoter methylation and high circulating A1AT levels have been found in pregnant women at late pregnancy. These data may suggest a novel epigenetic regulation of A1AT expression in the peripheral blood mononuclear cells of healthy subjects.

This is rather preliminary and based on a single non-WP:MEDRS source. JFW &#124; T@lk  21:02, 10 September 2020 (UTC)