Talk:Amitriptyline

Breastfeeding contradiction in article
In the opening paragraph of the article it states " Use during breastfeeding does not appear to be a problem.[9]"

However under Contraindications section, it also includes breastfeeding, which means it shouldn't be prescribed while breastfeeding.

What's the deal with that? Both sources check out, 9 is Drugs.com and 4 is Medicines.org.uk but they contradict each other. Shouldn't it at least be mentioned in the article that there is differing information on breastfeeding while on Endep? — Preceding unsigned comment added by 106.69.150.110 (talk) 17:36, 28 June 2015 (UTC)

Pharmacological failure
Under the subheading: Pharmacogenetics

I have not heard this term before, 'pharmacological failure', and even searching the Googs was not helpful.

Maybe a better description, or link to an explanatory Wikipedia entry, or external link, would be useful.

AndrooUK (talk) 10:21, 26 October 2015 (UTC)

Log P
There is two values mentioned in the literature for log P of amitriptyline, 4.92 and 5.04, both citing to the same reference: Hansch C, Leo A, Hoekman D. 1995. Exploring QSAR. Hydrophobic, electronic and steric constants. Washington, DC: American Chemical Society. If someone has access to this book, please check which value is the correct one.--Tanevala (talk) 09:46, 2 February 2017 (UTC)

Text
I am not seeing amitriptyline called the "gold standard".

The 2018 review did not conclude "Another meta-analysis from 2018 found Amitriptyline to be the most effective drug in a comparison of 21 antidepressants."

So reverted Doc James (talk · contribs · email) 21:04, 9 December 2018 (UTC)


 * Sorry, my mistake. I mixed up the references. Now corrected. See p.134. — Preceding unsigned comment added by MorlocksAndEloi (talk • contribs) 22:02, 9 December 2018 (UTC)

Withdrawal aka discontinuation syndrom missing
Amitriptyline has a strong potential to result in discontinuation syndroms. Not noted in the article — Preceding unsigned comment added by 141.45.12.244 (talk) 16:04, 29 December 2018 (UTC)
 * Are there reliable medical sources (WP:MEDRS) to support this claim? -- Ed (Edgar181) 17:55, 29 December 2018 (UTC)

Clarity - for non-medical professionals
Hi

I wanted to know what it does, chemically. I have studied A level biology.

"Amitriptyline inhibits neuronal reuptake of serotonin and noradrenaline from the synapse in the central nervous system; this increases their availability in the synapse to cause neurotransmission on the post synaptic neurone."

That is the most unexplaining explanation I have come across in a long time.


 * "the synapse in the central nervous system" - which one? Does this mean "a synapse"?


 * "in the synapse" - the same one again?


 * "to cause neurotransmission on the post synaptic neurone" - where is this then?

Is "the" synapse the only one it works on? Should it be "a synapse" and "that synapse"?

I was going to wikify it, as that would at least allow one to read an explanation of what the "post synaptic neurone", and "neuronal uptake" was.

"Amitriptyline inhibits neuronal reuptake of serotonin and noradrenaline across the synapse (node) of a neuron in the central nervous system, preventing the neuron sending the 'message' from re-absorbing the chemical signals it has made in the node; this increased availability in the synapse gives more chance to cause neurotransmission on the post synaptic neuron, the one receiving and relaying the message."

Any good? Chaosdruid (talk) 17:41, 16 August 2019 (UTC)