Talk:Amoxicillin/clavulanic acid

Untitled
There is no mention of what this medication is ment to treat!!!
 * So "antibiotic with an increased spectrum of action and restored efficacy against &beta;-lactamase producing amoxicillin-resistant bacteria" isn't informative enough? Techelf 12:07, 15 Mar 2005 (UTC)

The indication for the use of this agent varies based on locale, population, and established bacterial resistance patterns in the community. For example, at my old center in Ann Arbor, MI, we often used a first-generation cephalosporin for uncomplicated urinary tract infections in children. At my current center, in the Bronx, NY, we use this agent for the same indication because the resistance patterns in our population are different. Mike 01:55, 3 June 2006 (UTC)

Refrigeration
The article says co-amoxiclav should be refrigerated. However, the written instructions which accompany augmentin pills from my local pharmacy say they should be kept at room temperature. Is the article inaccurate? -- Zarvok | Talk 22:15, 30 June 2007 (UTC)

It means the liquid preparation. Duly changed. Panthro 23:14, 22 July 2007 (UTC)

Veterinary Use
Co-amoxiclav is not banned from use in food producing animals in Europe. It is in fact licensed for cattle and pigs in the UK at least for the following conditions: Cattle: -Respiratory infections -Soft tissue infections -Metritis -Mastitis -Enteritis in calves

Pigs: -Respiratory bacterial infections in growing pigs -Colibacillosis -Periparturient infections in sows

It is available in the UK as oral boluses for calves, injectable and intramammary preprations. Jamez654 (talk) 11:08, 16 May 2008 (UTC)

Allergic?
Some people are actually allergic to this product (including myself, iyeru42.) Would someone like to confirm this via a notability search or something? I'm busy with other stuff elsewhere. =/ 68.190.115.253 (talk) 16:40, 15 June 2008 (UTC)


 * Article already notes in the side effects section "Amoxicillin is a member of the penicillin family of antibiotics, and therefore should not be taken by patients allergic to penicillin" This article does not need dupicate in any greater detail the information found in amoxicillin article nor then in turn of Penicillin. David Ruben Talk 17:52, 15 June 2008 (UTC)

You can be allergic to augmentin without being allergic to other antibiotics of the penicillin family, due to the presence of clavulanic acid, see article. 169.147.3.25 (talk) —Preceding undated comment added 19:47, 16 June 2011 (UTC).


 * I'm only allergic to augmentin so far, nothing else in the family. 68.190.126.248 (talk) 18:21, 31 May 2013 (UTC)

Move
Should be moved to the gerneric names Amoxicillin with clavulanic acid Doc James (talk · contribs · email) 21:39, 18 November 2009 (UTC)

Duplicate text?
Some of this text is identical to that on www.medic8.com/medicines/Augmentin.html TamaraStaples (talk) 08:44, 7 July 2010 (UTC)

Dosage
I'm currently on these, and both the information leaflet and the prescription say I should take 3 x 500/125mg a day, far higher than what it says in this article86.155.77.146 (talk) 16:08, 30 August 2010 (UTC)

I too am currently on these with a dosage of 3 x 500mg/125mg a day, I believe this is the standard dosage in the UK. They also come packed in packets of 3 tablets per strip, 1 strip per day. — Preceding unsigned comment added by 82.30.154.63 (talk) 11:39, 21 June 2011 (UTC)

History?
The article states that the combination was 'invented' around 1977/1978. Please state a source for that claim. The EMA-published EURD list lists the European Reference Date as 7 March 1972 (www.ema.europa.eu/docs/en_GB/document_library/Other/2012/10/WC500133159.xls). — Preceding unsigned comment added by 195.34.187.34 (talk) 06:28, 7 July 2014 (UTC)

Auto-Archive?
There is some old material sitting here without further replies. Perhaps we should start Auto-Archiving this Talk Page. The Mysterious El Willstro (talk) 05:05, 12 April 2012 (UTC)

Merge or cross reference?
Should there be a cross-reference to, or perhaps merge with, Clavulanic acid? PraeceptorIP (talk) 14:48, 6 July 2015 (UTC)
 * Clavulanic acid is half of this compound. And we link to potassium clavulanate in the first paragraph. Doc James  (talk · contribs · email) 04:07, 9 July 2015 (UTC)

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Sensitivity to humid environment ?
Each 14-tablet carton of GSK-branded 875 mg Augmentin contains two (hermetic) aluminum packets, with each packet containing a 7-tablet (hermetic) blister pack AND a desiccant sachet. The packets bear note of 30-day expiry following packet opening. This packaging implies extreme sensitivity to humidity. Yet, other Augmenting-equivalent tablets I have seen - under various brand names - use simple 7-tablet blister packages, without any evident anti-humidity measures.

I wonder if this is a real issue, and if it is - whether it should be mentioned here. Thanks - Chaim Cshenorr (talk) 15:51, 31 March 2024 (UTC)


 * That is the case. Here is a source for you to use if you want to add that content:
 * ":Esubalew Asres, Thomas Layloff, Ayenew Ashenef,
 * Development and validation of a high-performance thin layer chromatography method for the simultaneous determination of amoxicillin and clavulanic acid combinations in tablet dosage forms,
 * Heliyon,
 * Volume 9, Issue 12, 2023
 * https://doi.org/10.1016/j.heliyon.2023.e22891.
 * (https://www.sciencedirect.com/science/article/pii/S2405844023100995)
 * And the relevant quote:
 * ":AMX and CLA are highly sensitive to moisture and temperature conditions. As CLA is hygroscopic and thermolabile, the storage conditions should be continuously maintained at 15–24 °C and 20 % relative humidity (RH)
 * The article is available for free on PMC here.
 * Kimen8 (talk) 16:42, 31 March 2024 (UTC)
 * The article is available for free on PMC here.
 * Kimen8 (talk) 16:42, 31 March 2024 (UTC)