Talk:Ancestral sequence reconstruction

Merge from Paleoenzymology
The Paleoenzymology article covers similar ground as the #Resurrected proteins section of this, it's one of multiple applications of ASR (along with protein engineering). I'd suggest merging it in for now until such time as there is sufficient information to warrant a split. T.Shafee(Evo &#38; Evo)talk 06:56, 23 April 2019 (UTC)
 * I tend to agree although I would prefer to keep them separate, simply because my understanding of Paleoenzymology is more structural: you don't need any seqeunces to study "ancient" enzymes. If you have structures you can do that simply based on the structure(s) of the active site(s) (even though I agree that this may be nearly impossible, given that structural analysis is almost always dependent on sequences). But sure -- a bit more substance would be helpful :) Peteruetz (talk) 00:04, 29 June 2019 (UTC)
 * Support merge, given that Paleoenzymology is long-standing stub and is a subset of Ancestral sequence reconstruction. It could certainly have its own section, but it is a subset of the broader topic. There is nothing unique about enzymes compared with other proteins; you still need the sequence, and for any protein you can use current structures to infer likely ancient structure. Functional assays can also be carried out for proteins other than enzymes. Klbrain (talk) 05:33, 5 April 2020 (UTC)
 * ✅ Klbrain (talk) 20:32, 19 June 2020 (UTC)