Talk:Androgen prohormone

Reverted Edits
Alteripse reverted a my edits over complains i removed important content. The content i removed was:


 * A third dimension of deceit involves their legal classification: most "prohormones" are sold as dietary supplements to avoid the much tighter efficacy and safety requirements of the Food and Drug Administration which apply to prescription hormones.


 * Prohormones are legally sold in most parts of the world and are classified in the United States by the FDA as dietary supplements because they consist of compounds that occur naturally in the human body; however their use remains quite controversial and side effects are not uncommon. 

In my view the content above is no longer justified since (as the article says) prohormones were made illegal in the united states.

And i also added:


 * Prohormones are also illegal in many European countries.


 * It is also marketed as a form of anti-aging and for those who wish to lose weight.

Ok - so maybe you didn't agree with me moving the text around but was just attempting to make it easier to understand and read.

Please explain why the content i removed is required and why what i added is not relavent or true.

johnSLADE (talk) 10:31, 16 August 2005 (UTC)

I had no objection to the insertion of either statement. There were 2 principal reasons I reverted. First, the continuity made less sense to go right from a paragraph describing the general concept of a prohormone, to a mention of a localized law restricting sale of a product based only tenuously on the general concept. A better organization is:
 * General definition of prohormone and biological examples
 * The specialized cultural use of the term prohormone in the context of bodybuilding.
 * Specific details about this type of prohormone, including the unproven efficacy and fraud issues, and legal aspects of use in various locations.

My second objection was your removal of the sentence describing the marketing of prohormones as dietary supplements as a form of misleading marketing. I realize some might disagree, but removing a sentence like that without explanation or justification is likely to produce reversion.The banning in a sense supports the inference of misleading marketing but I am confident we will see products marketed the same way that are no better or more honest than the banned ones. I had no objection to insertion of a paragraph on the new law, or your other facts, so feel free to replace them without the deletion.

Does that make sense? alteripse 21:48, 16 August 2005 (UTC)

Comment on this page: Suggest to check a REAL medical dictionary before accepting the Jan09 Wikipedia definition

Whatever happened to the term, "pre-hormone"? According to Stedman's Medical Dictionary, "A pro-hormone is "an intraglandular precursor to a hormone". Examples are pro-insulin, pro-PTH, thyroglobulin.

The present article about Pro-hormone shows gross confusion with the term, Prehormone, which according to Stedman's Medical Dictionary is "A glandular secretory product, having little or no inherent biologic potency, that is converted peripherally to an active hormone." eg. dehydroepiandrosterone, T4

Take care because Wikipedia is a very efficient way to propagate misinformation. —Preceding unsigned comment added by 207.188.88.150 (talk) 14:49, 14 January 2009 (UTC)

Why just androgens?
Androgens and anabolic steroids are not the only prohormones. I've taken estradiol valerate before, and that is a prohormone of estradiol. Synthroid is a prohormone of T4. Likewise, there are prohormones of insulin. As for the legal arguments, they would only apply to anabolic steroids. So the anabolic steroid and androgen bias needs to be removed, with less androgens listed in detail, and more of the other prohormones. I found this article through the thyroid article.--74.124.187.76 (talk) 16:35, 24 August 2009 (UTC)

Prohormone misinformation
A law was passed making only some pro hormones illegal. There are pro hormones that are legal like halodrol, tren and others. Often they are molecularly similar to steroids and are metholated to survive a pass through the liver. When they pass through the liver their molecular structure is altered to an actual steroid in some cases. This is why they cause a positive drug test for steroids. This article is inaccurate in it's law references and the information is very dated at best. —Preceding unsigned comment added by 66.177.249.81 (talk) 21:54, 19 July 2010 (UTC)

Banned list
androstanediol-- 3b,17b-dihydroxy-5a-androstane; and 3a,17b-dihydroxy-5a-androstane; androstanedione (5a-androstan-3,17-dione); androstenediol-- 1-androstenediol (3b,17b-dihydroxy-5a-androst-1-ene); 1-androstenediol (3a,17b-dihydroxy-5a-androst-1-ene); 4-androstenediol (3b,17b-dihydroxy-androst-4-ene); and 5-androstenediol (3b,17b-dihydroxy-androst-5-ene); androstenedione-- 1-androstenedione ([5a]-androst-1-en-3,17-dione); 4-androstenedione (androst-4-en-3,17-dione); and 5-androstenedione (androst-5-en-3,17-dione); bolasterone (7a,17a-dimethyl-17b-hydroxyandrost-4-en-3-one); boldenone (17b-hydroxyandrost-1,4,-diene-3-one); calusterone (7b,17a-dimethyl-17b-hydroxyandrost-4-en-3-one); clostebol (4-chloro-17b-hydroxyandrost-4-en-3-one); dehydrochloromethyltestosterone (4-chloro-17b-hydroxy-17a-methyl-androst-1,4-dien-3-one); 1-dihydrotestosterone (a.k.a. `1-testosterone') (17b-hydroxy-5a-androst-1-en-3-one); 4-dihydrotestosterone (17b-hydroxy-androstan-3-one); drostanolone (17b-hydroxy-2a-methyl-5a-androstan-3-one); ethylestrenol (17a-ethyl-17b-hydroxyestr-4-ene); fluoxymesterone (9-fluoro-17a-methyl-11b,17b-dihydroxyandrost-4-en-3-one); formebolone (2-formyl-17a-methyl-11a,17b-dihydroxyandrost-1,4-dien-3-one); furazabol (17a-methyl-17b-hydroxyandrostano[2,3-c]-furazan); 13a-ethyl-17a-hydroxygon-4-en-3-one; 4-hydroxytestosterone (4,17b-dihydroxy-androst-4-en-3-one); 4-hydroxy-19-nortestosterone (4,17b-dihydroxy-estr-4-en-3-one); mestanolone (17a-methyl-17b-hydroxy-5a-androstan-3-one); mesterolone (1a-methyl-17b-hydroxy-[5a]-androstan-3-one); methandienone (17a-methyl-17b-hydroxyandrost-1,4-dien-3-one); methandriol (17a-methyl-3b,17b-dihydroxyandrost-5-ene); methenolone (1-methyl-17b-hydroxy-5a-androst-1-en-3-one); methyltestosterone (17a-methyl-17b-hydroxyandrost-4-en-3-one); mibolerone (7a,17a-dimethyl-17b-hydroxyestr-4-en-3-one); 17a-methyl-*1-dihydrotestosterone (17b-hydroxy-17a-methyl-5a-androst-1-en-3-one) (a.k.a. `17-a-methyl-1-testosterone'); nandrolone (17b-hydroxyestr-4-en-3-one); norandrostenediol-- 19-nor-4-androstenediol (3b, 17b-dihydroxyestr-4-ene); 19-nor-4-androstenediol (3a, 17b-dihydroxyestr-4-ene); 19-nor-5-androstenediol (3b, 17b-dihydroxyestr-5-ene); and 19-nor-5-androstenediol (3a, 17b-dihydroxyestr-5-ene); norandrostenedione-- 19-nor-4-androstenedione (estr-4-en-3,17-dione); and 19-nor-5-androstenedione (estr-5-en-3,17-dione; norbolethone (13b,17a-diethyl-17b-hydroxygon-4-en-3-one); norclostebol (4-chloro-17b-hydroxyestr-4-en-3-one); norethandrolone (17a-ethyl-17b-hydroxyestr-4-en-3-one); oxandrolone (17a-methyl-17b-hydroxy-2-oxa-[5a]-androstan-3-one); oxymesterone (17a-methyl-4,17b-dihydroxyandrost-4-en-3-one); oxymetholone (17a-methyl-2-hydroxymethylene-17b-hydroxy-[5a]-androstan-3-one); stanozolol (17a-methyl-17b-hydroxy-[5a]-androst-2-eno[3,2-c]-pyrazole); stenbolone (17b-hydroxy-2-methyl-[5a]-androst-1-en-3-one); testolactone (13-hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid lactone); testosterone (17b-hydroxyandrost-4-en-3-one); tetrahydrogestrinone (13b,17a-diethyl-17b-hydroxygon-4,9,11-trien-3-one); trenbolone (17b-hydroxyestr-4,9,11-trien-3-one); and any salt, ester, or ether of a drug or substance described in this paragraph - —Preceding unsigned comment added by 66.177.248.18 (talk) 17:04, 2 August 2010 (UTC)

1-test
Where's the reference for it being bitter and needing transdermal application? Searle never persued it because it was bad for the liver. It is highly orally available compared to other AASs in any of its three forms: undecanoate, ester, or ethyls. And it was also "known" as a real steroid because it actually was one. Duh. The whole "pro" or precusor thing was an attempt to get around the law. -Reticuli 66.178.144.182 (talk) 09:06, 23 April 2011 (UTC)

Pre-hormone
What is the difference between a prohormone and a prehormone? I'm somewhat ignorant on this matter, but I seem to find these terms used interchangeably in some contexts.Jimjamjak (talk) 11:51, 7 May 2012 (UTC)


 * I think what everyone or some may be forgetting or overlooking is 1. The introduction of a outside source of a substance Prohormone, prehormone, or even a precursor hormone. And 2 the bodies own natural prehormone, precursor, prohormone, hormone cascade.


 * A pro-hormone is a incomplete hormone that uses a enzyme found in the liver, stomach, Skin, or somewhere in the body to turn into a complete hormone. Something like M1,4ADD (17a-methyl-1,4-androstadiene-3b,17b-diol) or (17a-methyl-androst-1,4-diene-3b,17b-diol) is one not discussed in this article but could be along with many others.


 * A pre-hormone as I understand it is a biochemical substance secreted by glandular tissue, have no significant hormonal action but is converted into active hormone in peripheral tissue. This pertains almost exclusively to medical terms and processes within the body. Except now we have things like IGF-1LR3, IGF DES, HMG,MGF, Peg-mgf, CJC1295, CJC1295 with DAC, PT-141, HCG, melanotan II, melanotan I, GHRP-6, GHRP-2, Semorelin, Frag 176/191, Hexarelin, Ipamorelin, Follistatin 344, GDF-8 all being sold under research chemical laws that people are taking. These could be considered Pre-hormones.


 * A precursor is an inactive substance converted to an active one (such as an enzyme, vitamin, or hormone). The term "precursor" applies to any chemical that is transformed into another. That which precedes another or from which another is derived, applied especially to a physiologically inactive substance that is converted to an active enzyme, vitamin, or hormone, or to a chemical substance that is built into a larger structure in the course of synthesizing the latter. The major hormone secretions of the ovaries and testes are steroid hormones, which are all synthesized from the same precursor: Cholesterol which by definition of the author of this article is now a band substance lol. Read more: http://www.answers.com/topic/sex-hormone#ixzz2P0uskecB


 * Another good example would be DHEA along with all its known derivatives like 7-keto-DHEA and Epiandrosterone (3â-hydroxyetioallocholan-17-one; 3â-hydroxy-5á-androstan-17-one) All of which are not only not on the list of banned drugs/steroids but are specifically mentioned as not banned in the http://www.deadiversion.usdoj.gov/fed_regs/rules/2005/fr1216.htm


 * This Article lacks a ton of references, Its wrong on more levels then I even have time to fix and it led me to about 30 other articles on Wiki connected to this one that are also wrong on just as many levels. Thanks Needtogetaas — Preceding unsigned comment added by Needtogetaas (talk • contribs) 10:09, 30 March 2013 (UTC)

comment 1
Dear Wikiproject, I see no mention of Vitamin D which is infact not a vitamin but a prohormone. This is not purely intracellular as it has to be ingested prior to conversion in at least two known sites of the body. Insufficient levels of the hormone derived from the prohormone can now be implicated in significant disease processes affecting virtually every cell type within the human body Mick russon (talk) 08:36, 9 May 2013 (UTC)


 * Mick, I think an easier way is to rename this article; something like "Prohormonal nutritional supplements." This article has little to do with the general topic of precursors to physiologic hormones and is focused on anabolic supplements. — Preceding unsigned comment added by 50.163.81.19  (talk • contribs) 06:51, 25 November 2014  (UTC)

Drug interactions
Anyone have any information regarding interactions with other drugs, specifically alcohol? I couldn't find anything at first glance on google. — Preceding unsigned comment added by Mferrante123 (talk • contribs) 23:57, 2 March 2015 (UTC)

unsourced 1
the following is unsourced - moved here per WP:VERIFY:

A typical prohormone is intended to be a precursor of an anabolic steroid like testosterone, which is taken in order to boost the body’s available hormone supply. These precursors are intended to be converted to full, active hormones via an enzymatic process that occurs during metabolism, typically resulting in the addition of whichever atoms happen to be missing from the chemical structure of the compound.

Prohormones are used mainly by athletes looking to increase size, strength, endurance, reduce recovery time or add lean body mass. They are most often used for increasing muscle mass or reducing body fat levels. Life extension groups are also increasingly using prohormones as a means of hormone replacement therapy, as an alternative to prescription drug use. Additionally there is a movement to use prohormones of androgens to help offset the damaging effects of environmental estrogens on the body. Chemical endocrine disruptor agents like bisphenol A are becoming recognized as having the ability to skew the androgen to estrogen ratio. This skewed ratio can have many adverse effects on men, including sexual performance, impotence and other testosterone dependent body functions.

The use of prohormones has become popular among bodybuilders, since the effects can be similar (though normally much less drastic) to those achieved through the use of synthetic anabolic steroids, including gains in muscular strength and hypertrophy. There are currently many companies manufacturing prohormone products for this purpose.

Prohormones have the same side effects as anabolic steroids, and are dependent upon the user as to which side effects one might experience. Some side effects are acne, hair loss, breast tissue enlargement, and prostate swelling; however, these are specific to each type of prohormone, and reports of side effects are usually minimal.

The potential for these side effects does exist, but it can be reduced if one uses proper precautionary measures such as post cycle therapy (PCT). Generally, if a person is genetically predisposed to a side effect it will occur (i.e.: if someone has a history of male pattern baldness in the family, it could be assumed that this could be a side effect experienced if prohormones are used)

-- Jytdog (talk) 08:57, 12 April 2016 (UTC)

Complete overhaul?
This article contains numerous grammatical and syntactical errors, as well as unsourced statements or possibly "original research." In my opinion, it requires the attention of a seasoned editor and might benefit from a complete rewrite. Brianbbad (talk) 18:24, 18 May 2021 (UTC)