Talk:Angiopoietin

Mbeez (talk) 19:54, 7 October 2013 (UTC)

2013, proposed development
I am considering developing this page further as part of an educational assignment in Fall of 2013. If someone else is also working on this, please send me a message and let me know soon, so we donʼt duplicate initial efforts in page development. Choidah (talk) 22:49, 6 October 2013 (UTC)

Upon researching more information on angiopoietin it was possible to find valuable information on Madame Curie Bioscience Database. Here, there is useful information concerning the ligand Angiopoietin-1 and how it is expressed. There can be greater development in the mechanism by which angiopoietin forms new blood vessels. There is little information about how the receptor tyrosine kinase (RTK) works with angiopoietin but not enough information about the protein itself. The full citation for the text is Patan S. How Is the Branching of Animal Blood Vessels Implemented? In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK6295/ Choidah (talk) 03:33, 7 October 2013 (UTC)

Summary of additional material on article
Our article has had a substantial amount of new material added. Firstly, we have extended the general introduction of the angiopoietin proteins in terms of its mechanisms and relationships with other proteins and growth factors. We then provided more details on the specific mechanisms of angiopoietin-1 and angiopoietin-2 proteins. We focused on the tyrosine kinase pathway and its importance with the angiopoietin protein family. Specifically, the receptor and ligand interactions and the other factors such as VEGFs, PFGFs, and HSC signaling that influence the downstream effects. We then focused on adding more information on the structure of the proteins. Specific facts including the amino acid number, the molecular weight, and the structural domains were added. Lastly, the clinical relevance paragraph was expanded upon. Consequences of angiopoietin dysregulation were discussed which can lead to diabetes, malaria, sepsis, and pulmonary hypertension. Treatment plans involving angiopoietin proteins were also added such as the method for tumor suppression via angiopoietin manipulation. Overall, the amount of new material explained the function and structure of the protein family and how it is relevant during and after development. Ran21 (talk) 05:46, 15 November 2013 (UTC) Mbeez (talk)Choidah (talk)

Peer Review, 2013
From josemags
 * wiki linking (things that should have a link to another article, but I'm not including what Vicktory7 already said)
 * 1st paragraph: Growth factors (in the first paragraph, remove the one in specific mechanisms), Cytokines, microvascular permeability (w/ redirect to vascular permeability), smooth muscle cells.
 * Specific mechanisms:Phosphorolation, enzymes, integrin and cadherin, extracellular matrix, osteoblastic cells (redirect to osteoblast), ligands, macrophages, glycoprotein, basal lamina, chemokines, autocrine signaling, paracrine signaling.
 * structure: Polypeptide. Include a See also line that links to Heterodimers
 * Clinical relevance: Well no one knows what a Tek stands for so I dont know what to link that to unless it stands for something previously mentioned in the article which wasnt made clear., squamus cell carcinoma, cardiovascular disease, dialysis, equilibrium (w/ a redirect to homeostasis), sepsis.


 * Readability (I would put the structure paragraph before mechanisms to allow for a better understanding of what carries out the mechanisms)
 * Intro
 * According to the wiki rules, the very first word should be the exact same as the article title. So it should not be pluralized (I know dumb rule, but I got called out on it by some wiki pro.)
 * Compared to the rest of the article this is the most straight forward and easiest to read. Remember youre not writing for bio majors, youre writing for the common person too.
 * Is there not a 3D structure for ang-1 and only a structure for ang-2?
 * I agree that the 3rd paragraph should be under specific mechanisms, but I think the 2nd paragraph is fine in the intro.


 * Specific mechanisms
 * That last paragraph seems to work best closer to the top.
 * "They are mostly exclusive..." They isn't really expressed. Just change that to the proper noun.
 * This is how I would break down the sub headings. 1) Functions (essentially the 3rd paragraph from the intro with a bit of expansion) 2. Tie pathway 2a. Tie-2 3. Ang 2
 * That is a very rough classification of the paragraphs that I provided, but overall that wall of text is hard to maneuver and understand.
 * Move things talking about ang1 and Tie 2 to sub section 2a.


 * Structure
 * The sentences here are extremely dense. Space the sentences out with more explanations of critical ideas like what dimerizing does to the structure, or what the super clustering domain is.
 * "Structurally, angiopoietins have an N-terminal super clustering domain, a central coiled domain, a linker region, and a C terminal fibrinogen-related domain which is responsible for the binding between the ligand and receptor." This should be towards the top of the paragraph.
 * Increase size of the thumbnail.


 * Clinical relevance
 * Definitely like Vicktory7 said separate into sub headings. Possibly like deregulation, (second paragraph has a bunch of different diseases talked about. maybe under one header that links them together, cancer treatment, and sepsis
 * Maybe include a photo that links to one of the diseases mentioned.


 * Overall conclusions
 * It's a nice article. It's missing some wiki links and could be a little clearer to read, but comparing to what there was here y'all put in a lot of work to make this article like 100x better. Great job.

Josemags (talk) 19:35, 24 November 2013 (UTC)


 * Introduction:
 * Great work giving a background to this family of growth factors, very sophisticated and knowledgeable information
 * Make sentences more concise, understandable (especially sentence about angiopoietin cytokines which should be more brief: “Angiopoietin cytokines are involved with controlling microvascular permeability. They also control vasodilation and vasoconstriction by signaling smooth muscle cells surrounding vessels.” “Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood cells.” —> go on to elaborate about angiogenesis mechanism/process under your “specific mechanisms” section.
 * 2nd and 3rd paragraphs should be considered to be placed under a sub section.
 * 2nd paragraph could be placed in the “structure” section
 * 3rd paragraph could be placed in “specific mechanisms” heading
 * Specific Mechanisms:
 * There is a ton of great info here but it is very easy to get lost without section structure to guide the reader. Very detailed outlines of mechanisms.
 * Tie-1 and Tie-2 articles should be linked
 * hematopoietic stem cell should be linked
 * “cellular components of the niche” —> what is the niche? Maybe this is just a new word to me.
 * endosteum should be linked
 * VEGF (move “vascular endothelial growth factor” to first mention of VEGF) and metastasis should be linked
 * Break this section into sub headings. Possible headings could be “Angiogenesis signaling” and “Vascular permeability signaling”
 * Structure:
 * Move the picture of “angiopoietin protein structure closer to the “Structure” heading
 * Clinical relevance:
 * Great job incorporating a multitude of ailments associated with angiopoietin and its molecular effects.
 * Consider grouping your referenced data into sub headings
 * multiple myeloma and Kaposi’s sarcoma should be linked

Vicktory7 (talk) 21:22, 21 November 2013 (UTC)


 * Introduction
 * The second and third paragraphs should be moved underneath the table of contents, perhaps create a section that talks about the diversity of the angiopoietin proteins/which ones are known.
 * You mention angiogenesis in the lead paragraph, but then you don't mention it in the body. I would create a separate section that relates the process of angiogenesis and how each of the Ang proteins participate.  The point of the lead paragraph is to give a brief overview of what the reader will find in the main article without giving away substantive details.
 * Specific mechanisms
 * There's a lot here, and I got lost trying to read all of it. You have many sources that deal with angiogenesis.  Like I mentioned before, I suggest creating a subsection on angiogenesis since it's an important mechanism.
 * Link more things. Basically, if you can define something, you should link it because it probably already exists on Wikipedia.
 * Perhaps consider a section that talks about what cells are involved in its production, which could be a nice segue into the clinical relevance section.
 * Structure
 * I feel this should be the first section because it gives readers a visual representation of the proteins they are reading about.
 * The first two sentences should be moved to another paragraph saying how Tie proteins are associated with the Ang proteins' structure. But, you should start with the third sentence that gives details about the components that build Angiopoeitin-1.
 * Clinical Relevance
 * Good job with this section. Again, I encourage linking many of the topics you have here.
 * Other comments
 * Provide a 'See also' page so people can learn more about the processes mentioned or the proteins involved (i.e. Tie proteins, angiogenesis, etc.)
 * Again, good job and good luck with everything!

SOTTET05 (talk) 23:08, 24 November 2013 (UTC)

Response to Peer Reviews
I'd like to take a moment to both thank and respond to all of the reviewers! Your input has been incredibly helpful. Your suggestions will be taken into account soon.Mbeez (talk) 19:55, 4 December 2013 (UTC)

2016 update
[http://www.genengnews.com/gen-news-highlights/sepsis-antibody-shrinks-tumors-and-improves-drug-delivery/81253548 Sepsis Antibody Shrinks Tumors and Improves Drug Delivery. Dec 2016] relates to the ANG-2, Tie signalling. Could be useful. - Rod57 (talk) 11:09, 11 February 2017 (UTC)