Talk:Antidepressant treatment tachyphylaxis

Specifically SSRIs or not?
In the introduction "ADT tachyphylaxis specifically refers to a sudden decrease in response to selective serotonin reuptake inhibitors (SSRIs), which are the most commonly prescribed antidepressants" This statement has two citations. Then, further down in the "Common examples" section "ADT tachyphylaxis specifically occurs in depressed patients using SSRIs and MAOI" The Common examples section has one citation. Something should be done about this. 75.71.166.197 (talk) 21:49, 2 November 2022 (UTC)

How to assess tolerance
antidepressants have limited efficacy, with effect size 0.3, corresponding to 10% symtom reduction. Most of the effect (30%) in acute treatment is due to placebo effect and/or regression to the mean. How then can one assess if a person has tolarance, rather than just a worsening of symtom due to the natural course of depression?

This makes antidepressant switching or combination an illogical treatment for "tolerance". Evaluating the psychological and psychosocial causes or trying other types of treatment might be more reasonable. 217.213.92.129 (talk) 10:41, 29 June 2024 (UTC)