Talk:Antipain

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 27 January 2020 and 8 May 2020. Further details are available on the course page. Student editor(s): Wendtiga.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:26, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 1 September 2021 and 6 December 2021. Further details are available on the course page. Student editor(s): Quokkaz.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:26, 17 January 2022 (UTC)

Ovid
Publius Ovidius Naso published a paper about Nelfinavir?? What an hoax ...

Radix--2003:F5:EF0C:8456:4893:76EF:33B8:5EF4 (talk) 16:27, 25 June 2021 (UTC)

Sections removed
I removed a couple of sections from the article and placed them here (below). Much of this content is inconsistent, contradictory, confusing, and/or just plain wrong. The probelm is probably related to the school assignment described above. A few examples:
 * "Protease inhibitors or antipain are enzymes" - antipain is not an enzyme
 * "a study published by Ovid" - Ovid lived 2000 years ago
 * "Antipain is a protease inhibitor ... and is well-against to cathepsin A" - what does that even mean?
 * "DRUG neurons" - what are drug neurons? (why DRUG neurons, not drug neurons?)

If anyone can make sense of it, correct it, and fix the poor writing then it can be added back into the article.

In addition, the remaining content of the article should be checked for accuracy. Marbletan (talk) 19:43, 25 January 2024 (UTC)

== Antiretroviral and protease inhibitors == There are several serine proteases, which are enzymes that cleave the protein bond, in the human genome. Proteases are ubiquitous. Protease function is also affected by endogenous inhibitors. The abnormal functioning of these proteases can lead to the development of cancerous tumors. Protease inhibitors or antipain are enzymes that are used to regulate their performance. The antiretroviral drug Nelfinavir is one example of an antipain. It was classified as an antipain after a study published by Ovid that investigated the in vitro effect of Nelfinavir using proteolytic foot printing and found that it selectively inhibited HER2- positive, a growth factor in breast cancer. Antipain is a reversible inhibitor of trypsin, papain, and, plasmin, which is isolated from actinomycetes.

Protease inhibitors and DRUG neurons
Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors activated by proteolytic cleavage of the receptor N terminus. PARs are activated by some Serine Proteases and are important for the physiological, psychological, and pathological functions of the human body. During the study, an antipain analogue Y was developed and studied. It was shown to have properties as a protease inhibitors but it had a low IC50 than a antipain. Antipain analogue Y was able to suppress Trypsin, which inhibits the secretion of an excitatory neuropeptide that leads to inflammation and other disorders. Antipain is a protease inhibitor, usually 1–2 μg/mL, and is well-against to cathepsin A, cathepsin B, papain and trypsin protease enzymes.