Talk:Aplastic anemia

Question
Epidemiology keeps saying "blood marrow." Do they mean bone marrow?

Question: What does "aplastic" mean in this context?

I updated the page to say what it is aplastic means the bone marrow is dead or dying (not producing blood cells)

These are my first contributions to wikipedia, I'm not entirely familiar with all the controls yet... Had a bit of trouble figuring out the "talk" thing. Hope I've got it right. bjb, 2003/03/14


 * Plastic has the meaning of formative, and more specifically in relation to biology, the capacity of forming living tissue. In aplastic anemia the bone marrow loses the ability to give rise to peripheral blood cells. -- Someone else

P.S. You found the talk OK.

Helpful information that should be added to this page should be that there is now another treatment that is proving to be durable,that provides a treatment-free remission, through the use of High-Dose Cyclophosphamide Therapy. The original study is reported in the Annals of Internal Medicine: http://www.annals.org/cgi/content/abstract/135/7/477 mjd, 2006/01/06162.84.63.150 15:07, 29 January 2006 (UTC)


 * thanks! You could also be bold and make this one of your significant edits to Wikipedia articles. JFW | T@lk  17:49, 29 January 2006 (UTC)

SBDS
Mutations in SBDS (Schwachman-Diamond) found in AA:. JFW | T@lk  06:38, 7 August 2007 (UTC)

I don’t have a source (other then a friend who has this disease) but only 300-500 people in the USA are diagnosed with this disease each year.

LIVE ON
HEY, IAM 26 YRS OLD MARRIED AN A 6YR OLD SON I HAVE BEEN IN REMISSION FOR 21 YRS. I WOULD LIKE TO KNOW IF MY SON WILL HAVE HEATH PROMBLEMS LATER IN LIFE. NO ONE CAN TELL ME ANYTIHNG? I HAVE LOOK FOR IMF. TO SEE IF THERE WERE ANY STUDYS TO SEE IF COULD BE PASS ON. AN WHAT TO LOOK FOR AN HOW OFFEN DOSE HE NEED TO BE CHECKED. —Preceding unsigned comment added by 207.54.197.40 (talk) 08:56, 14 December 2008 (UTC)


 * Ask your doctor, don't use Wikipedia for this because you have no way of knowing whether the answer will be from a reliable source. JFW | T@lk  07:31, 16 September 2009 (UTC)

My brother recently died from aplastic anemia... My mother also died at a young age from the disease. YES have your son checked... —Preceding unsigned comment added by 99.71.255.251 (talk) 08:18, 23 March 2010 (UTC)

Guidelines
UK guidelines for diagnosis: JFW |  T@lk  07:31, 16 September 2009 (UTC)

Marie Curie
"Later examination of her bones showed that she had been a careful laboratory worker and had a low burden of radium. A more likely cause was her exposure to unshielded X-ray tubes while a volunteer medical worker in WWI[citation needed])"

This assertion is contradictory to statements in the Wikipedia article on Curie, also uncited: "Her death on 4 July 1934 at the Sancellemoz Sanatorium in Passy, in Haute-Savoie, eastern France, was from aplastic anemia, almost certainly contracted from exposure to radiation. The damaging effects of ionizing radiation were not then known, and much of her work had been carried out in a shed, without taking any safety measures. She had carried test tubes containing radioactive isotopes in her pocket and stored them in her desk drawer, remarking on the pretty blue-green light that the substances gave off in the dark."

It would be nice if someone could actually do some research and provide a reference for either of these assertions. It seems very doubtful that they both could be accurate. 97.127.68.3 (talk) 02:49, 10 June 2010 (UTC)


 * Agreed. Perhaps it should be removed until a citation is found.190.213.80.14 (talk) 14:58, 24 June 2010 (UTC)

Lancet 2005
10 years old but it was the latest general review article I could find. Anything more recent? Lancet. 2005 May 7-13;365(9471):1647-56. Aplastic anaemia. Brodsky RA, Jones RJ. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2805%2966515-4/abstract DOI: http://dx.doi.org/10.1016/S0140-6736(05)66515-4 "Acquired aplastic anaemia can be effectively treated by allogeneic bone-marrow transplantation, immunosuppression (generally antithymocyte globulin and ciclosporin), and high-dose cyclophosphamide."--Nbauman (talk) 12:30, 31 July 2015 (UTC)

Guideline
From the UK Haematology guideline body: 10.1111/bjh.13853 JFW &#124; T@lk  21:42, 17 November 2015 (UTC)

Hereditary or not?
In the intro it is stated "common causes are heredity [...]" but the causes section says "It is not a hereditary condition, [...].". That sounds contradictory to me? If the intention is to say "causes can be hereditary, but the condition itself is not" that should probably be clarified. 2A02:8071:3184:79C0:1D72:C2F4:7EA7:C119 (talk) 07:08, 1 March 2023 (UTC)