Talk:Autophagy

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 24 August 2020 and 1 July 2021. Further details are available on the course page. Student editor(s): MeggoKeggo. Peer reviewers: Xeczeed, At2118.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 15:04, 16 January 2022 (UTC)

Autophagy as a link between SARS-CoV-2 and Cancer
There is a recent hypothesis published in a well-known journal in the field of oncology regarding Autophagy being a potential link between SARS-CoV-2 and cancer (https://www.mdpi.com/2072-6694/13/22/5721/htm). Prof. Daniel Klionsky (https://en.wikipedia.org/wiki/Daniel_J._Klionsky) a well-known scientist in the field is among the authors of this work. Should this proposed link be included in this Wikipedia page as well?

Auto-destruct sequence
Programmed cell death says the organelles are destroyed "in a specific sequence", and I want to know what it is. —Keenan Pepper 04:17, 23 July 2006 (UTC)
 * Based on the sequence of essential operations I'd guess, which might vary on the type of cell and it's current state. Them genes is pretty complex. Tyciol (talk) 17:43, 29 November 2008 (UTC)

Merge from self-cannibalism?
Since this is basically the same thing as self-cannibalism, and the article even says so, why not merge the two? Wikipedia's not a dictionary. Trappleton 08:31, 19 August 2006 (UTC)
 * Oppose - Autophagy, in medical terminology, refers to a specific form of cell death. The term is synonymous with self-cannibalism only in general usage. These are two distinct phenomena that deserve seperate articles. ˉˉanetode╦╩ 08:28, 19 August 2006 (UTC)
 * Oppose. Two different things, two different articles. —Keenan Pepper 09:35, 19 August 2006 (UTC)
 * Oppose. - The two are entirely distinct topics, which therefore justifies separate wikipedia entries. I find the fact that the issue is even up for discussion rather surprising. Sober Disposition 22:15, 29 August 2006
 * Oppose.autophagy is a normal and even necessary process in cell biology. Most of the time it's like a turnover rather than a nutritional process. Self-cannibalism its an aberrant behaviour.--Gustavocarra (talk) 20:37, 18 November 2007 (UTC)

Programmed cell death
The article claims there is no conclusive evidence pointing to this being a type of programmed cell death, but I had a lecture a few weeks ago by the head of a haematology research lab who claimed it definitely was. I may be wrong - she was a bit of an idiot. —Preceding unsigned comment added by Andykinosis (talk • contribs) 03:54, 6 April 2008 (UTC)

The organization of this section is somewhat confusing. The beginning of the paragraph appears to assert that it is an established fact that autophagic PCD exists, yet it goes on to present arguments that cast doubt on that assertion. It seems to me that it may be appropriate to rewrite this section to better reflect the speculative nature of the existence of autophagic PCD? Or could it be the case that there new information has been published on the topic which hasn't been incorporated into this article? Hsa-mir-122 (talk) 03:28, 4 October 2013 (UTC)

Autophagy and its connection to PCD is still not fully understood. So far it appears to correlate in certain settings, but if one is the cause of the other or vice versa is not known, nor whether their correlation is universal. — Preceding unsigned comment added by 129.241.158.85 (talk) 00:23, 3 November 2016 (UTC)

Apoptosis and autophagy are both forms of PCD, they are related to each other but functions are totally different, pcd occurs from foetus stage. Maheeth pattem (talk) 05:01, 9 May 2017 (UTC)

Diseases and possible treatments
Could we have a section for diseases that are due to malfunctions of autophagy, and possible treatments for them. Maybe Alzheimers, Parkinsons and Huntingdons diseases? Scientific American May 2008 says Rapamycin 'induces' autophagy. Rod57 (talk) 13:20, 5 October 2008 (UTC)


 * [What an information-dense article!] Could aberrant autophagy result in malabsorption of nutrients in humans? Is that an example of autophagy in LRBA mutation? Thank you for your time, Wordreader (talk) 23:30, 13 March 2021 (UTC)

See also metabolic syndrome and autophagy at http://www.sciencedaily.com/releases/2009/04/090401145310.htm —Preceding unsigned comment added by 24.181.230.194 (talk) 20:37, 2 April 2009 (UTC)

Calorie restriction/cutting
Periods of subnormal nutrition (macronutrients usually rather than micro) occurs during calorie restriction and the cutting phases that bodybuilders use. I am wondering if it would be possible to expand upon the relation of these and the higher health seen in some bodybuilders and calorie restrictors who do so in combination with a healthy lifestyle and optimal micronutrients. Tyciol (talk) 17:43, 29 November 2008 (UTC)

Redirect issues
Currently autophagy redirects to autophagy (cellular) anyway, so how come we don't move this to autophagy? I would see the 'cellular' in parenthesis as only necessary if there were some other form of autophagy that had an article, making autophagy a disambiguation page rather than a redirect. Another option would be moving this to autophagocytosis which is also mentioned here, and looks nice and fancy and all. Tyciol (talk) 17:45, 29 November 2008 (UTC)

how macroautophagy is initiated is still under a big question mark.
So far,it's might be too early to define the function of PI3K class III in macroautophagy. The hVpS34 (PI3K Class III) has been reported to form different complexes with different partners and these complexes may play distinct roles on autophagy. In additon, the hVpS34 has also been recognized as a sensor to transduce signals from extracellular amino acids to mTOR complex I, which is supposed to inhibit autophagy. Oremine woo (talk) 18:21, 11 April 2009 (UTC)

The signaling complexes upstream of autophagy is very complex. PI3K (hVsps34) is one signaling protein in one of many pathways known to regulate of autophagy. But also hVps34 have pleiotropic functions independent of autophagy. take a look at figure 2 from this science article: http://science.sciencemag.org/content/330/6009/1344.full — Preceding unsigned comment added by 129.241.158.85 (talk) 00:28, 3 November 2016 (UTC)

Pronunciation
I'm always confused as to the pronunciation of Greek and Latin derived words. Is it auto-fagy or auto-fajy? —Preceding unsigned comment added by 69.90.55.168 (talk) 02:14, 30 September 2009 (UTC)

Also, where does the accent go? I'm guessing aw-TOF-uh-jee. — Preceding unsigned comment added by 70.127.26.247 (talk) 02:29, 8 May 2018 (UTC)

Review Articles?
In a medical article, the very recent references would be queried if they're not review articles. Should the recent refs be checked for this project? RDBrown (talk) 12:18, 19 November 2012 (UTC)

Strange sentence in intro

 *  In the context of disease, autophagy has been seen as an adaptive response to survival, whereas in other cases it appears to promote cell death and morbidity.

A "response to survival"? How do you respond to survival? And this (presumably positive?) response we see only in the context of disease, whereas in other contexts autophage promotes morbidity? Isn't morbidity the same as disease? AxelBoldt (talk) 21:59, 29 September 2013 (UTC)

1: Autophagy is one of many surivival response mechanisms that cells initiate as part of attempting to better adapt to a challenging environment. The typical example is that of starvation, where autophagy is a survival mechanism and thus become activated.

2: In some settings activation of autophagy appears to promote progression of disease, where as in other diseases its activation appears to protect against progression.

So i suggest to change the text to clarify these two main points — Preceding unsigned comment added by 129.241.158.85 (talk) 00:33, 3 November 2016 (UTC)

External links modified
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Autophagy and neurodegenerative disease
I have changed the parkinson's disease section to become more general as it is known that autopahgy is linked to a range of other neurodegenerative diseases. Thus in hopes that this section becomes expanded in the future — Preceding unsigned comment added by 129.241.158.85 (talk) 00:36, 3 November 2016 (UTC)

Orphaned references in Autophagy
I check pages listed in Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of Autophagy's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.

Reference named "test": From End-of-life care:  From Suicidology:  

I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT ⚡ 11:13, 23 June 2021 (UTC)

Type 2 Diabetes Connection to Crinophagy
"'Excessive activity of the crinophagy form of autophagy in the insulin-producing beta cells of the pancreas could reduce the quantity of insulin available for secretion, leading to type 2 diabetes'" Type 2 diabetes is more related to insulin resistance and not insulin secretion. From the article it stems that reduced insulin production leads to type 2 diabetes. I wonder if this is mentioned in the cited source. It is behind a paywall and would be great if someone with access could check it. In general more info on crinophagy is needed in the article. --Motikor (talk) 17:35, 4 January 2022 (UTC)

Water only Fasting
￼o mention of longer term water only fasting despite numerous studies showing it initiates autophagy. https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=water+fasting+autophagy&btnG=

2A00:23C6:8499:BB01:C9D5:A319:F222:267F (talk) 21:02, 13 May 2023 (UTC)