Talk:Batten disease

copyvio??
Is this page plagiarized from the National Institutes of Health page at http://www.ninds.nih.gov/disorders/batten/detail_batten.htm, or did they copy from here? If the former, shouldn't credit be given?
 * If you look at the bottom of the NINDS page, you will see this notice: "All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated." That said, it certainly would be good manners to acknowledge authorship.-- H-ko (Talk) 09:08, 14 July 2007 (UTC)

Piracetam
The nootropic drug piracetam appears to significantly reduce lipofuscin in the brain tissue of rats. (Paula-Barbosa, M. et al, "The effects of Piracetam on lipofuscin of the rat cerebellar and hippocampa; neurons after long-term alcohol treatment and withdrawal", Alcoholism: Clinical and Experimental Research 15, (1991) pp. 834-838.). Does it have any effect on Batten's disease? If not, why not? Lipofuscin accumulation is a symptom of aging and alcoholism; understanding mechanisms for its elimination are useful for the general populace as well as sufferes of Batten disease. (Piracetam does appear to be effective in treating symptoms of alcoholism). linas 19:46, 15 July 2007 (UTC)


 * Some google searches:
 * A casuistic rationale for the treatment of spastic and myocloni in a childhood neurodegenerative disease: neuronal ceroid lipofuscinosis of the type Jansky-Bielschowsky.  Author:   Lorenz, R   Citation:   Neuroendocrinol-Lett. 2002 Oct-Dec; 23(5-6): 387-90


 * Savvas Papacostas Contact Information, Elena Kkolou and Eleftherios Papathanasiou Published online: 23 January 2007 Abstract  We present three unrelated cases of genetically confirmed progressive myoclonic epilepsy of the Unverricht–Lundborg type who were treated with Levetiracetam as adjunctive therapy for their myoclonus. All cases responded with decrease of their myoclonus and improvement of quality of life. Two were able to return to or continue their employment. Patients tolerated the drug well without side effects reported. Levetiracetam appears to be a useful antimyoclonic agent in cases of progressive myoclonic epilepsy and should be considered for adjunctive therapy.

Random bleeding
The only place I've seen an assertion of "random bleeding" and inflammation of nerve endings is where the Wikipedia article has been copied. The assertion seems far-fetched and odd, so I've removed it. If a reliable source can be found it can be reinstated and properly documented. Myron 11:12, 16 July 2007 (UTC)

Treatment Section
The "Treatment" section has very limited citations. Additionally, there appears to be a contradictory statement within the text. Two clinical trials using fetal cell transplantation have been discussed (2005 and 2007), but only the trial performed by StemCells, Inc. is referred to as the "first clinical trial transplanting fetal stem cells into brains of BD patients." Yet the 2005 trial is stated to have used fetal neural cells. Since no citations for the 2005 clinical trials are provided, I cannot confirm the source of the stated cells and determine whether or not the StemCells, Inc. trials are indeed the "first" to transplant fetal STEM cells. Anyone have information on the 2005 trials referred to in this article? Wiki emma johnson (talk) 00:55, 7 September 2009 (UTC)

Overall
There is an overall absence of the scientific explanation of Batten Disease in this article. Wiki emma johnson (talk) 01:00, 7 September 2009 (UTC)

External links modified
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Confusing focus - juvenile Batten or all of the NCLs?
It seems unclear whether the page is about CLN3 juvenile Batten disease or all of the NCLs; it jumps back and forth. Since the introduction mentions this and links to page which describes the NCLs as a whole, I would propose editing the article so that it focuses on juvenile Batten and remove the table that lists all of the genes causing other forms of NCL, since this information can be found on the NCL page.

I'm also planning to expand the 'Cause' section to give a better overview.

I'd appreciate any thoughts on that! Gor4kd (talk) 04:25, 14 November 2016 (UTC)

External links modified
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Attention needed
Just to note that the intro states Batten disease to be a fatal disease - in fact it is the general name given to all of the neuronal ceroid lipofuscinoses - clear in refs given.--Iztwoz (talk) 16:16, 27 December 2019 (UTC)

They're all fatal. Tyrekecorrea (talk) 16:32, 27 December 2019 (UTC)

...Well, technically, Kufs Disease is only stated to shorten the lifespan of the patient. Are you going to change the intro, Iztwoz? Tyrekecorrea (talk) 16:44, 27 December 2019 (UTC)


 * To be clearer the intro states it is a fatal disease instead of stating that it is the general name given to the NCLs. And i just noted it here as cannot see myself editing it in near future. --Iztwoz (talk) 16:49, 27 December 2019 (UTC)

Well, most of these diseases are categorically fatal; that could be mentioned along with the name encompassing a group of diseases. Tyrekecorrea (talk) 17:11, 27 December 2019 (UTC)