Talk:Biopharmaceutical/to do

This list is incomplete, please discuss and add more.


 * Biopharmaceutical development (see: drug development) and approval process (preferably fow-sheet):
 * Rational drug design and combinatorial chemistry approach (in brief)
 * Patenting of biopharmaceuticals (USPTO, EPO, etc)


 * Classification:
 * Nucleic acid therapeutics (Gene therapy, antisense technology, etc.)
 * Recombinant proteins: Subunit vaccine
 * Antibody based therapeutics: monoclonal antibodies, etc.


 * Delivery (see: drug delivery):
 * Oral, pulmonary, nasal, transmusocal and transdermal delivery systems.


 * Uses:
 * Focus: Development of AIDS vaccine (see: HIV vaccine).
 * Focus: Gene therapy and cancer (also AIDS).
 * Focus: Gene therapy and cancer (also AIDS).


 * Large scale production:
 * Details of platforms i.e. mammalian cell, yeast cells, insect cell, plant cell culture and whole-plants.
 * Their relative advantages and disadvantages (preferably in tablular form).
 * to include biological production of hormones, interferons, etc from genetically engineered cells (pathways, sources, cell line).
 * Downstream processing (filtration, etc)


 * Others:
 * Proteomics in biopharmacetical drug development and diagnosis of disease.
 * Enzymes in clinical diagnostics (clinical enzymology) - biosensors - microanalysis kit development.


 * Purity, efficacy, potency, safety, cost, etc.:
 * Regulation by authorities like US FDA, European Commission, etc.


 * Ethics: public concern in
 * Gene therapy (in vivo): human germ line
 * Genetic modification of plants and animals for our benefit
 * Cost vs. degree of action


 * Acceptance by society:
 * Factors involved...


 * Business of biopharmaceuticals: 
 * Industry statistics (sales, etc.)
 * Companies (Amgen, Biogen, Genentech, Boehringer Ingelheim, etc.)




 * References:


 * External links:
 * Please add