Talk:Bivalirudin

WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:24, 10 November 2007 (UTC)

Indications
We often use bival for HIT; is this an official indication? If so, it's not listed. Obviously this might just be the standard off-label sort of thing... 71.248.114.201 (talk) 20:06, 9 November 2008 (UTC)

needs updating according to new study results?
why does the page say "Bivalirudin ... overcomes many limitations seen with indirect thrombin inhibitors, such as heparin" when Bivalirudin was inferior to heparin in both efficacy and safety in a recent study published in the lancet: Shahzad et al. 2014. Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial. — Preceding unsigned comment added by Andywhatever (talk • contribs) 00:37, 8 December 2015 (UTC)

External links modified
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 * Added archive https://web.archive.org/20120426012238/http://angiomax.com/Downloads/Angiomax_PI_2010_PN1601-12.pdf to http://angiomax.com/Downloads/Angiomax_PI_2010_PN1601-12.pdf

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External links modified
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 * Added archive https://web.archive.org/web/20120426012235/http://www.themedicinescompany.com/new-images/Angiox-PIs/emea-combined-h562en.pdf to http://www.themedicinescompany.com/new-images/Angiox-PIs/emea-combined-h562en.pdf
 * Added archive https://web.archive.org/web/20150203135952/http://angiomax.com/downloads/Angiomax_US_PI_June_2013.pdf to http://www.angiomax.com/downloads/Angiomax_US_PI_June_2013.pdf

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Ambiguity pitfall in the term "reversible"
I've removed language in a couple of places (one of them in the first sentence of the lead section) that called bivalirudin "reversible", although I've left in place the explanation in the section "Basic chemical and pharmacological properties", which makes it clear that the term "reversible" refers to the mode of binding at the molecular level. The language "reversible" in other places misleadingly suggests the existence of a specific clinical reversal agent (antidote) that would reverse the clinical effects of bivalirudin, in the way that idarucizumab (Praxbind) reverses the effects of dabigatran (Pradaxa). No such specific clinical reversal agent exists for bivalirudin, and it is potentially dangerous to lead readers to think it does.

The "reversible" claim is from the manufacturer's prescribing information for bivalirudin, which presumes a professional readership. This is an illustration of the pitfalls of using language from professional literature directly in a source like Wikipedia, whose intended audience is the general public.

—Syrenka V (talk) 08:00, 2 February 2018 (UTC)