Talk:Brain natriuretic peptide

Obesity
I am no expert on BNP but I thought that it was reduced in obesity rather than higher? I can only see the abstract to Wang TJ, Larson MG, Levy D, et al. (2004). "Impact of obesity on plasma natriuretic peptide levels". Circulation. 109 (5): 594–600 - but it seems to bear this out ??? JScott16 (talk) 17:10, 26 June 2011 (UTC)

This
This should be the talk page, right?

What's that NPRA abbr. supposed to mean?

Natriutretic Peptide Receptor A Settersr 11:34, 15 July 2006 (UTC)

GC-B is the name of the particulate Guanylyl cyclase that is activated by BNP not another name for BNP

Units
There is a discussion of normal BNP levels versus levels that are considered to be elevated. However, there is no discussion of the units that BNP levels are measured in. I believe that BNP is typically measured in units of either pg/dL or pmol/L. Let's add a discussion of these units. When discussing a BNP level, e.g., "Values above 500 are generally considered to be positive", let's be sure to specify units. Finally, let's show how to convert between units. To convert a BNP level from pg/dL to pmol/L, I believe that you multiply by about 0.28, but don't take my word for it. Mark D Hardy 02:53, 1 April 2007 (UTC)

In addition, there is some clinical discussion about a values of BNP > 300 pg/dl as a more accurate (sensitive?) threshold in clinical medicine to determine acute congestive heart failure (CHF). Like many diagnostic serum values, it is used in addition to physical symptoms and imaging to assess what disease state a patient is in. Sethgale 12:53, 19 June 2007 (UTC)

Uninformative
I moved the following sentence here because I think it needs specification why it is so fantastic: Mikael Häggström (talk) 08:52, 30 March 2010 (UTC)

"With a few limitations, BNP has been deemed as "A biomarker for all the right reasons"."

Brain Natriuretic Peptide or Basic N... P...?
The title of the article is "Brain..." which seems to be correct, but the article starts out "Basic..." with no explanation. Natkuhn (talk) 00:16, 27 December 2012 (UTC)

I agree with Natkuhn's comment. The term used need to be consistent. I think it will be more appropriate to use B-type Natriuretic Peptide at the beginning and through out the paper as this is the recongised term since it has been changed from "Brain Natriuretic Peptide". — Preceding unsigned comment added by 122.107.155.33 (talk) 03:40, 29 April 2013 (UTC)

I agree with User 122, that the article should be moved to "B-type natriuretic peptide". Also, I am very much surprised that there is no explanation of why the substance was ever called "brain NP".   Solo Owl   23:44, 11 September 2019 (UTC)

Missing link to the article on BNP in German
Hi! I have accidentally run upon the article on BNP in German, but could not add the link to it. Some internal problem seems to occur, when Wiki checks that page. URL of the German page: http://de.wikipedia.org/w/index.php?title=Brain_Natriuretic_Peptide&oldid=117334752 Katerynf (talk) 06:43, 7 June 2013 (UTC)

One AA seems to be missing
As I understand the article, preproBNP is 134 AA long. When AAs numbered 1-25 are removed, we get proBNP (which could be assumed to be 134-25=109 AAs, right?). When AAs numbered 103-134 are removed, BNP-32 is formed and left is NT-proBNP consisting of AAs numbered 26-102 (right?). But AAs numbered 26-102 are 77 AAs (102-25 = 77). In the article one reads "BNP is secreted attached to a 76-animo acid". Something seems to be wrong somewhere.

Btw, what is the half-life of pro-BNP? This information is missing where half-life is discussed. — Preceding unsigned comment added by 130.239.42.222 (talk) 09:47, 2 July 2017 (UTC)

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Two new sections needed
Anyone care to take on adding sections on Receptors and Physiologic effects? See Atrial natriuretc peptide article which has these sections: I presume comparable info is available for BNP. Regards IiKkEe (talk) 15:41, 7 September 2017 (UTC)

Subject matter and references in section titled "Measurement"
By my count these are 24 references in this section: 22 of them are original research, strongly discouraged by WPMOS. So the statements in this section read more like a review article than a WP article, since it is reporting on the findings and significance of original research. Also the table may be a copyright violation, even with attribution.

I am not familiar with who in WP adjudicates these kinds of things, so I will not pursue. I'm pointing it out for anyone who does know how. IiKkEe (talk) 17:40, 11 September 2017 (UTC)