Talk:Branched-chain amino acid

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2019 and 19 December 2019. Further details are available on the course page. Student editor(s): DrScienceGuy. Peer reviewers: Bigcmemmott1, Biophysstudent.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 18:18, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Ismail sayeedi.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 16:11, 16 January 2022 (UTC)

Two revisions
I made two revisions. First, I deleted the "reference" to "Testosterone Nation." "Testosterone Nation" is a marketing website for Biotest, a supplement company that sells branch chain amino acid supplements. Marketing material hardly qualifies as a "reference."

Second, I deleted the "The Importance of BCAA" section. That read like a supplement ad and lacked supporting references.

People should be able to come to Wikipedia to learn about substances without being bombarded by supplement company hype.

Good call on both fronts :)

Spuddddddd 21Jan09 —Preceding unsigned comment added by 131.111.35.22 (talk) 10:50, 21 January 2009 (UTC)

I'm deleting a bit more, "According to fitness experts...", the link provided was to a supplement company, also deleted. Kurtdriver (talk) 05:09, 13 September 2016 (UTC)

Burn victims
Theres a peer reviewed paper that might lend weight to the notion BCAAs can help burns victims below, no reference was supplied to qualify this statement in the text http://jn.nutrition.org/cgi/content/full/136/1/308S Badgernoid (talk) 11:12, 7 May 2009 (UTC)

Absorption by muscle
Where is a source for the fact that BCAAs are absorbed directly by muscle tissue? I will dlete this until a source can be supplied. This sounds like great supplement company advertisment. —Preceding unsigned comment added by 24.103.24.95 (talk) 19:00, 29 January 2010 (UTC)

Insulin resistance
There's a theory that high levels of BCAAs (in combination with fat) contribute to insulin resistance. (at http://www.sciencedaily.com/releases/2009/04/090407130905.htm ) 98.221.156.200 (talk) 16:25, 31 January 2010 (UTC)

BCAA catabolism
There is a small section here in this article for BCAA degradation. This may be worth expanding into a full article. I'll try to come back to it soon but don't have time today. There are a ton of additional biochemical genetic diseases that relate to these pathways. MSUD is only the beginning. Also: Isovaleric acidemia, Propionic acidemia, methylmalonic acidemia, Beta-ketothiolase_deficiency, 3-Methylcrotonyl-CoA_carboxylase_deficiency, HMG CoA Lyase deficiency. The more typical illustration of BCAA catabolism is a different diagram. I'll also work on getting a diagram together. It would look something like what is here: https://dmd.aspetjournals.org/content/dmd/39/7/1155/F1.large.jpg

1/3 of skeletal muscle – please, clarify
1/3 of what? Almost any tissue consists of more than 2/3 water (mass fraction). Incnis Mrsi (talk) 19:54, 11 April 2010 (UTC)

What about instantized amino acids? there should be a section explaining what they are — Preceding unsigned comment added by 108.20.210.55 (talk) 14:17, 16 January 2015 (UTC)

Bodybuilding supplement
BCAA is often taken as a body building supplement. Should this be mentioned? Is there any good evidence that it helps build muscle (ie. compared to people who don't take it)? —Preceding unsigned comment added by 60.241.132.22 (talk) 08:24, 17 May 2010 (UTC)

yes http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1135117/pdf/biochemj00224-0256.pdf

also they are commonly used in bodybuilding circles more often to help prevent muscle breakdown when trying to burn fat rather than during the stages of building muscle. — Preceding unsigned comment added by 211.30.30.85 (talk) 10:09, 25 June 2012 (UTC)


 * Working on collecting useful secondary source journal articles that address the bodybuilding controversy. Individual clinical trials are so variable in dose, duration, nature of exercise and the tested population that citing these would be counter-productive. Tentatively, will include reviews by Negro M 2008 and Salinas-Garcia ME 2014. Both conclude that BCAAs supplementation does not appear to improve exercise performance, but may help with delayed-onset muscle soreness (DOMS), post-exercise muscle protein synthesis, and perhaps some other exercise recovery factors.David notMD (talk) 04:02, 6 January 2017 (UTC)

I reverted change to article by 185.156.38.71 because no references were provided.David notMD (talk) 21:50, 12 January 2017 (UTC)

Sources?
I know a lot of the bodybuilding crap was removed from this article thankfully because there are no sources other than from the companies who design these supplement products but if this is to be considered something that builds muscle mass, there needs to be scientifically reviewed (see journal articles) that prove this. Otherwise, I think it is misleading for there to be any information in here that says branched amino acids contribute to skeletal muscle hypertrophy. The only source verified claim is its use in burn victims. -Novaprospekt (talk) 03:04, 25 May 2010 (UTC)

This site mentions a scientific study http://www.exrx.net/Nutrition/Supplements/BCAA.html I appreciate the concerns about using evidence from supplement suppliers, but to not mention it's use by body builders and strength athletes at all seems equally perverse. — Preceding unsigned comment added by 83.35.250.3 (talk) 23:32, 23 December 2012 (UTC)
 * Agreed. I'm here precisely to find out more about its function in sports nutrition. Wikipedia, you are letting me down (not that I mind that much, heh heh). Anyway, if BCAAs are considered to be one of the snake oils of our century then that should surely be part of the article. 92.25.15.35 (talk) 23:48, 8 October 2013 (UTC)

BCAAs and mice longevity
BBC has an article here, pubmed abstract here --Mongreilf (talk) 20:02, 6 October 2010 (UTC)

Twelve common ones?
I can't understand what "of twelve common ones" means in the sentence "There are three branched-chain amino acids leucine, isoleucine and valine of twelve common ones." I looked at the source and the linked page, but they did not help. Can someone familiar with this term explain it for the rest of us? TIA Wakablogger2 (talk) 07:28, 24 October 2010 (UTC)
 * yeah I couldn't understand that either. I rewrote the sentence.Trueno Peinado (talk) 18:40, 1 December 2010 (UTC)

Can I recommend the University of Arizona's page:- http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aa.html which describes the 20 amino acids that the body uses to make proteins. 10 it can make for itself which are alanine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine and tyrosine. 10 it has to obtain from its diet are arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. Body building supplements tend to contain leucine, isoleucine, valine and arginine as the manufacturers claim they help in muscle repair and growth. —Preceding unsigned comment added by 86.26.155.32 (talk) 16:49, 7 May 2011 (UTC)

http://en.wikipedia.org/wiki/Branched_Chain_Amino_Acids
Why are there two pages for BCAA's? Seems the other page is just an advertisement for BCAAs as a supplement. — Preceding unsigned comment added by 67.71.197.131 (talk) 20:54, 26 July 2011 (UTC)


 * Looks like its now fixed. 67.198.37.16 (talk) 00:50, 21 June 2021 (UTC)

Illustration
I'm not quite seeing how the illustration at the bottom of the article has any relevance to BCAA's (am I missing something?) doctorwolfie (talk) 15:01, 30 July 2012 (UTC)

Commercial Content
I tried removing a link to a commercial site selling supplements as part of a general cleanup. This has now been reverted and re-added in with a fairly non-sensical review message:

https://en.wikipedia.org/w/index.php?title=Branched-chain_amino_acid&action=historysubmit&type=revision&diff=746402769&oldid=746402308

by a certain Alexbrn, who seemed unwilling to discuss. I plan to remove his link to the supplement site in the next few days. Be interested to know if anyone can see any reason to keep it, or if it's just spam. — Preceding unsigned comment added by 111.223.127.242 (talk) 08:27, 28 October 2016 (UTC)
 * Not great sources, but at least they are only supporting the "claims" made for BCCA and are RS for that. Your edit introduced health effects for which these sources are not WP:MEDRS. Better sources for the claims made for BCCA would be good. Alexbrn (talk) 08:45, 28 October 2016 (UTC)


 * My edit introduced no sources which were not already there. This is easily verified with a click above and a few seconds of your attention. You appear to be a heavy user of Wikipedia, and so your claims to not see this seem somewhat disingenuous. Nothing in your supplement-selling-website link introduces a claim not in the other articles, making it all the more puzzling why you're insisting on retaining links to commercial affiliate sites here. 172.56.6.80 (talk) 09:21, 28 October 2016 (UTC)
 * I didn't say you introduced new sources, but you did use them for purposes for which they are unreliable. I am not "insisting" on the sources, but am insisting that if they're used they're used appropriately: to repeat, better sources would be good. Are there some? Also knock off the ABF shit and WP:FOC. Alexbrn (talk) 09:36, 28 October 2016 (UTC)

Effects of BCAAs on Exercise
Hi, I'd like to add a section on the effects of BCAAs on how it may increase protein synthesis and what occurs with its supplementation after exercise.

Thanks! — Preceding unsigned comment added by Ckong46 (talk • contribs) 21:20, 30 October 2016 (UTC)
 * We include what reliable sources say, rather than pre-deciding a view to express. Are there good sources on this? Alexbrn (talk) 22:39, 30 October 2016 (UTC)


 * Alexbrn - I think have found two useful reviews (Negro M 2008 and Salinas-Garcia 2014 ), but want to read them very carefully before bringing their conclusions into the muscle/exercise/bodybuilding debate. A complicating factor is that serious exercisers - especially bodybuilders - are already consuming more protein (and likely more BCAA rich whey protein) than the protein RDA of 0.8 g/kg body weight, and so may already be consuming so much BCAAs that a supplement on top of all that would be meaningless.David notMD (talk) 04:16, 6 January 2017 (UTC)

Hello, I am working on a class assignment and am helping edit this page under drsusan1968. I added some information under cell signaling about the subject. You may want to look more into the source in this section. — Preceding unsigned comment added by Cellbioclass123 (talk • contribs) 14:02, 31 October 2016 (UTC)

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BCAA effects on exercise
Hey there! I was thinking of making a section on BCAA and its effects on exercise and recovery. I found a really good article as well as some others I would like to use to substantiate the section. Thanks! DrScienceGuy (talk) 23:30, 3 November 2019 (UTC)