Talk:Breast cancer management

Possibly copyright violation
I just barely split article out from main Breast cancer page. I will scan the article and try to rewrite/paraphrase where possible to avoid copy violation. Consider this a hang on tag for a couple hours until I can do this. Optigan13 05:51, 13 October 2007 (UTC)
 * You don't have to rewrite it, since the source is Wikipedia. You just have to attribute the parent article for GFDL compliance reasons. I'll do it below and on the article page. --  But | seriously | folks   05:53, 13 October 2007 (UTC)

LN as indication for XRT
I changed the XRT section from "4 or more LNs" (paraphrasing here) as an indication for post-mastectomy XRT (PMRT) to "substantial involvement" as an indication. The 4 or more recommendation is predominantly based on subset analysis from the randomized Danish PMRT studies. Similar subset analyses demonstrate that the 1-3 positive LN patients have the same relative survival benefit as those with greater numbers of LNs, even with 8 or more nodes removed (median in the study was 7 LN removed, and this has formed the basis for the argument that fewer LNs involved probably do not require PMRT if "adequate" surgery (10 or more nodes) is performed). Three randomized studies have shown a survival benefit for PMRT in node positive patients, while one has not. Thus, the NCCN advocates PMRT for all women with 4 or more nodes involved and "strong consideration" for women with 1-3 nodes involved. I feel the new wording is more permissive in allowing consideration of PMRT in all node positive patients (micromets or IHC excluded, hence the "substantial" wording) rather than just in those women with 4 or more positive nodes. Schwartzenator (talk) 04:47, 20 May 2008 (UTC)

Immuno Therapy
This section is a copy/paste of its source.--Mandor (talk) 14:12, 2 March 2009 (UTC)

No mention of Abraxane/Paclitaxel
Article doesn't seem to mention Abraxane (a formulation of Paclitaxel) which was approved by the FDA in 2005 for treatment of refractory breast cancer. Rod57 (talk) 19:51, 12 June 2010 (UTC)

Lymphedema section looks like a huge copy from somewhere
Includes lots of references at the end. No wikilinks. Is it worth editing or should it just refer to Lymphedema ? - Rod57 (talk) 21:53, 15 December 2015 (UTC)

External links modified
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pipeline
The table and "preclinical" sections below were an ambitious effort by somebody to track the pipeline of drug candidates for breast cancer. Content is mostly unsourced or based on primary sources and outdated. Questionable whether this sort of detail belongs in WP per WP:NOTNEWS as well

Other types of targeted therapies that are being researched to fight cancer include:


 * Angiogenesis inhibitors. These antibodies prevent the growth of new blood vessels, cutting off the supply of oxygen and nutrients to cancer cells.
 * Signal transduction inhibitors. These antibodies block signals inside the cancer cell that helps the cells divide, stopping the cancer from growing.
 * Antibodies/antagonists for other hormones/receptors such as androgen receptors and prolactin receptors, which are present in a high proportion of breast cancers.


 * Preclinical

In the March 2007, edition of the scientific journal, Nature Genetics, researchers from Canada's McGill University reported that they had developed a potential drug target for treating up to 40 percent of breast cancers by blocking an enzyme called protein tyrosine phosphatase 1B (PTP1B), which has been implicated in the onset of breast cancer in mouse models of the disease. Elevated levels of PTP1B have also been found in diabetes and obesity. A drug to block the activity of PTP1B is under development by Merck, and was found to delay the development of breast tumors and prevent lung cancer up to two months from the administration of the drug. The researchers hope to continue further research in mouse models which are also HER-2 positive (responsive to Herceptin) so that the drug could benefit a significant population of women.
 * Protein tyrosine phosphatase 1B (PTP1B)

It is possible that one mechanism utilized by PRIMA-1 to kill cancer cells may include shutting down cholesterol synthesis. What is now known is that Ro 48-8071 stops cholesterol synthesis, and it has been proved to be just as effective in destroying cancer cells as PRIMA-1, without harming other normal breast cells.
 * Cholesterol drug - Ro 48-8071

In experiments led by postdoctoral fellows Heather Hirsch and Dimitrios Iliopoulos, the combination of metformin and the cancer drug doxorubicin killed human cancer stem cells and non-stem cancer cells in culture. The researchers used four genetically distinct breast cancer cell lines.
 * Antidiabetic

In mice, pretreatment with the diabetes drug prevented the otherwise dramatic ability of human breast cancer stem cells to form tumors. In other mice where tumors were allowed to take hold for 10 days, the dual therapy also reduced tumor mass more quickly and prevented relapse for longer than doxorubicin alone. In the two months between the end of treatment and the end of the experiment, tumors regrew in mice treated with chemotherapy alone, but not in mice that had received both drugs. By itself, metformin was ineffective in treating tumors.

Modern advancements in hyperthermia biology have led to refinements for individualised thermochemotherapy approaches to treatments as well as interesting potential for exploiting hyperthermia in conjunction with cancer vaccines. MR imaging is playing an increasing role for measuring patient response to hyperthermia.
 * Thermochemotherapy

Interest in hyperthermia as a treatment for breast cancer has led to significant advances and research activity which, in turn, has had a significant impact on treatment protocol. The National Comprehensive Cancer Network (NCCN) now includes hyperthermia in their Breast Cancer Guidelines as a treatment for recurrent cancer.

Erasmus Medical Centre in the Netherlands is one of Europe's largest hyperthermia centres.

ThermoDox is a proprietary heat-activated liposomal encapsulation of doxorubicin, an approved and frequently used oncology drug for the treatment of a wide range of cancers including breast cancer. ThermoDox, which is administered intravenously and in combination with local hyperthermia, has the potential to provide local tumor control and improve quality of life. Localized mild hyperthermia (39.5-42 degrees Celsius) releases the entrapped doxorubicin from the liposome. This delivery technology enables high concentrations of doxorubicin to be deposited preferentially in a targeted tumor.

Testing of flaxseed (the highest source of mammalian lignans) on rats led to reduction and regression of tumours. This led to a formal randomized, placebo-controlled, double-blind study involving 32 postmenopausal patients confirming that 25g flaxseed daily intake significantly reduced cell proliferation, increased apoptosis and reduced c-erbB2 expression of human breast cancer cells. The preliminary research into flax seeds indicates that flax can significantly change breast cancer growth and metastasis, and enhance the inhibitory effect of tamoxifen on estrogen-dependent tumors.
 * Flax

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-- Jytdog (talk) 15:43, 10 October 2016 (UTC)

External links modified
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