Talk:Bromelain

Untitled
What exactly is "rescrcin"?

The only word close to "rescrcin" I could find is "rescin". Some synonyms where given online (http://chemical.exactantigen.com/r/rescin.html)

synonym: rescitens; apoterin; normorescina; moderil; tenamine; resipal; cinamine; recitensina; cinnaloid; rescinnamin; rescinnamine; apolon; anaprel; reserpinin; rescidan; rescaloid; resealoid; rescinpal; cinatabs; reserpinene; reskinnamin; paresinan; anapral; cartric; tuareg; recinnamine; reserpinine; scinnamina; raurescine; rescamin; cinnasil; raupyrol; rescisan; raurescin

Can someone confirm that this is a typo and the correct word is "rescin"? My knowledge of particular enzymes is near absent. --Enigma 07:10, 14 February 2006 (UTC)

Possibly should be resorcin, Searching for resorcin and bromelain gives 365 hits whereas rescin and bromelain gives none. I have no (bio)chemical knowledge to evaluates the hits however Mwp 21:28, 6 March 2006 (UTC)


 * Problem, though - resorcin isn't an enzyme, it's a disubstituted benzene. DS 02:08, 9 March 2006 (UTC)

I simply took it out for now, until we know more. --Enigma 00:10, 10 March 2006 (UTC)

rescin and its synonyms are drug/chemical names. They are not related to enzymes. http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00112.txt --User:Hx

Cysteine Proteases
The author states that "Bromelain is a mixture of sulfur-containing protein-digesting enzymes". This is a very ambiguous statement. On first reading, I interpreted it to mean that it contained enzymes that digest sulfur-containing proteins. Since bromelain is a cysteine protease (or thiol protease, using the terminology of Fersht), I assumed the author misunderstood the nature of the enzymes classification-- a cysteine protease doesn't digest proteins containing sulfur, a cysteine protease has cysteine as the catalytic residue in the active site. However, on second reading I realized that was inconsistent with the hyphenation used. So, I will re-holster my flame thrower and simply complain about the sentence structure, which, if not actually incorrect, is certainly difficult to parse. Of course, in the time it has taken me to write this, I could have reworded the author's sentence to read more easily. Is that sort of tinkering encouraged or frowned upon in Wikipedia-land? Eesnyder24060 (talk) 22:05, 30 September 2008 (UTC)

Activity
This page does not discuss the proteolytic activity of the major enzymes in bromelain or the optimal enzymatic conditions. Is it an acid protease, neutral protease, basic protease, does it need cofactors, etc. Article is kind of weak, scientifically.Pdeitiker 16:28, 8 July 2007 (UTC)

There is research available on bromelain. I will work on adding citations on medical uses to this article.--Little Flower Eagle (talk) 22:03, 5 March 2009 (UTC)

I think it's important to mention that consuming bromelain, even that just occurring in pineapple fruit alone, tends to dissolve the tissues of the body it contacts. This can cause bleeding of the lips and the inside of the mouth. Can it also dissolve tissues of the stomach and intestines in sufficient quantity? In that case, an overdose can conceivably have fatal consequences.Joseph Meisenhelder (talk) 00:33, 4 June 2012 (UTC)

Finger prints
On episode 7 of series 5 of QI, they said that this substance will remove fingerprints from the finger. Is this true? -OOPSIE- (talk) 05:15, 1 January 2008 (UTC)
 * Apparently plantation workers wear gloves to prevent their hands being "eaten". Thedarxide (talk) 19:24, 15 May 2009 (UTC)

I saw that episode as well and I would very much like to see a source. Anyone? =) 213.47.144.254 (talk) 20:11, 1 August 2010 (UTC)

Predictive statements
I included the advert template because of the last sentence about Debrase® Gel Dressing: "Once the treatment is approved, it will be helping millions of patients world-wide." I feel like it presumes approval and a subsequent assistance to millions of people. I think that the sentence would benefit from being worded less assertively (ie. If approved, there are millions of patients world-wide that could benefit from this drug.) --Stiggs64 (talk) 02:13, 20 March 2008 (UTC)

Article cleanup
I've noticed some issues with this article: 1. The 5 boxes following the lede (is it meant to be a table?) is in an odd format. Perhaps it should be a list?
 * ☑ The data was formatted as a WikiTable, with 3 cells in the first row and 2 cells in the second. I think it was intended to be an InfoBox - but I couldn't find an appropriate one to use. I formatted as a right-aligned table, titled Bromelain characteristics. If a suitable InfoBox can be found, all the better.

2. The Components section states "Bromelain is a mixture of sulfur-containing protein-digesting enzymes", but this conflicts with the lede which states "Bromelain can refer to one of two protease enzymes extracted from the plant family Bromeliaceae, or it can refer to a combination of those enzymes along with other compounds produced in an extract".
 * ☑ Updated text to make the lede and the Components section agree.

3. In the Meat Tenderizing section, these two sentences are a bit confusing: "Historically, meat tenderizing enzymes were often injected into the muscle of a food animal while it was still living. This practice was deemed unethical, and has been largely discontinued, replaced with various postmortem application methods which are acceptable for lesser quality cuts." Does this mean the practice is still performed for 'better quality' cuts? Are these points relevant to this article, per se (as it seems to broadly apply to meat tenderizing in general, not specifically to Bromelain)? Additionally, these assertions lack citations (as do a number of other points made in the article).
 * ☑ Removed sentences in question.

4. In Medical uses:

a. This is rather weasel-wordy: "Bromelain can be used in a vast array of medical conditions. " This section, as a whole, lacks citations for many of the claims.
 * In Progress - I've changed the first sentence, but this entire section needs some help. I'm thinking of a table that shows something like Area of Use; Benefit (with citation); Counterclaim (with citation).

b. This sentence contradicts an earlier section, and contains a claim with no citation: "Bromelain is basically present in the stem of the pineapple and is good in reduction of weight."
 * ☑ Removed sentence in question.

5. In the Production section, this sentence seems like advertising: "This process is carried out in factories under strictly controlled conditions to assure microbiological quality and enzyme purity." In theory, this claim, while unreferenced, would (one hopes) apply to anything produced for consumption. Why make the point here? What's special about Bromelain production?
 * ☑ Removed sentence in question.

6. I'm uncertain that the Other plant proteases section is needed in the article, as it specifically addresses things other than Bromelain - it seems to belong in article(s) about plant proteases in general or specifically about those other plant proteases that are listed.
 * ☑ Removed last sentence in question, but left section.

7. I'm uncertain all of the External links are encyclopedically relevant.


 * ☑ Upon inspection, they're fine.

I'll research and address these over time. Others comments are most welcome. Thanks! --4wajzkd02 (talk) 23:44, 24 April 2009 (UTC)


 * Is there a reason the Lead-In introduces Bromelain as a supplement with medicinal value? It seems at least unnecessarily gratuitous, if not partial altogether. Bromelain isn't a medicinal property 'first', it's an enzyme that happens to have potential medicinal uses when taken as a supplement. 11:03, 15 October 2011 (UTC)

8. The last sentence under 'Potential medical uses': "As bromelain supplementation may affect heart rate, care should be used by those with heart disease." but there seems to be no reference to heart rate or heart disease in the cited material.johnstexas

Chittenden?
"In 1892, Chittenden, assisted by Joslin and Meara, investigated the matter fully (Trans. Conn. Acad. Arts Sci. 8, 281-308), and called it 'bromelin'. Later the term 'bromelain' was introduced and originally applied to any protease from any plant member of the plant family Bromeliaceae."

But who/what is Chittenden? or Joslin and Meara for that matter?


 * Found the paper in question and added a proper citation. Chittenden and Joslin have their own articles, but Frank Sherman Meara does not. Nfm (talk) 04:20, 14 April 2014 (UTC)

Temperature
The article states "At room temperature, the enzyme can survive at least a week even under multiple freeze-thaw cycles." Would someone explain what that could possibly mean? "Freeze-thaw" would seem to contradict "room temperature." — Preceding unsigned comment added by 75.72.206.153 (talk) 06:20, 12 October 2016 (UTC)

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Stinging sensation after eating pineapples?
There is a widely circulated claim that bromelain gives our tongue that stinging sensation when we eat too much pineapples.  Supposedly the enzyme damage the skin or the mucus in our mouth. But I can't find a good scientific reference. I've also heard some people questioning this claim, pointing to papaya (which also has protease but no stinging) and kiwi (which does not have protease but does sting sometimes) as counter-evidence, and suggestion calcium oxalate crystals as the alternative explanation. Regardless of whether bromelain is the answer, I think the notability of this claim warrant some coverage in the article. C9mVio9JRy (talk) 09:03, 13 June 2022 (UTC)

Is Bromelain an anti inflammatory?
Is Bromelain an anti inflammatory? 70.185.132.45 (talk) 14:02, 18 June 2022 (UTC)