Talk:C-reactive protein

New content
Hi, I'm putting new content based on recent studies... One of my colleague wrote a article about CRP and he was kind enough to let me put it online. Eridanis, 10-18-04


 * Please keep it concise and to the point. Has this been printed in a peer-reviewed publication? I'm asking because original research cannot be published on Wikipedia. A good review, however, is perfect. JFW | T@lk  07:43, 19 Oct 2004 (UTC)

Any objections to a section on Alzheimer's disease that mentions CRP is made by neurons in the brain as well as the liver? I have citations, of course. There's a whole body of literature that I'm not sure I'm ready to sum up about CRP and the complement system playing a role in the neurodegeneration seen in AD and other dementias. Also, if anyone has spent a lot of time on this page, I'd appreciate a suggestion for where to insert it. It seems to fit in parallel with other diseases, each with their own section, but I don't want to stick it as the first item and offend anyone who has put a lot of time into other diseases where CRP's role is more clear or more obviously important. -Thanks! --Mike (talk) 15:17, 29 October 2014 (UTC)


 * The logical place to put this would be in a new subsection in the clinical significance section. Per WP:MEDRS, secondary sources (i.e., review articles) are strongly preferred to support medical claims.  It looks like there are a number suitable source (see PubMed search). Boghog (talk) 15:30, 29 October 2014 (UTC)
 * Thanks. Great entry. 35.130.200.146 (talk) 23:05, 1 April 2023 (UTC)

Category
Should this be in instead of  ? --RobBrisbane 11:20, 14 September 2007 (UTC)

Not atherogenic
hrCRP is a marker of atherosclerosis burden, but there is now experimental evidence that CRP is not a cause but rather an epiphenomenon in atherosclerosis:. JFW | T@lk  12:16, 28 February 2008 (UTC)

arthritis
is CRP ALWAYS raised during inflammatory arthritis? --CarTick (talk) 02:50, 24 May 2011 (UTC)

Incomplete sentence
"This is based on the JUPITER trial that found that elevated CRP levels without hyperlipidemia benefited."

This sentence is incoherent: The JUPITER trial found that elevated CRP levels without hyperlipidemia benefited what? — Preceding unsigned comment added by 75.157.135.57 (talk) 14:00, 10 June 2012 (UTC)

Clinical significance and diagnostic use
I think these sections need combining and rearranging. CRP is mainly used as a non-specific marker of inflammation (e.g. see here), but the article currently doesn't reflect that - it starts talking about specific conditions where it's less important, like cancer and cardiovascular disease. Arripay (talk) 23:08, 4 August 2013 (UTC)

Redundancies deleted, rewording
Did the above; whole page still needs lots of work.

IiKkEe (talk) 05:30, 20 May 2014 (UTC)

Need more on non-hs-CRP test
We are told how the hs-CRP test is done, and how accurate it is, but how else is CRP measured and how accurate is that ? - Rod57 (talk) 13:32, 13 September 2015 (UTC)

Assessment comment
Substituted at 10:37, 29 April 2016 (UTC)

Normal concentration info is confusing
It is said that "normal concentration in healthy human serum is between 5 and 10 mg/L", but few lines before it is said that people with CRP concentration higher than 3.0 mg/L have a high risk of cardiovascular disease. If you connect these two sentences, you will get that "normal" is something that has "high risk". --Mkevac (talk) 22:56, 19 December 2017 (UTC)
 * Yes, I noticed that too. I have no idea where that 5 - 10 number came from.  Maybe it's a typo?  The LabCorp (USA) reference range is 0 - 5, and I double checked the link the 0 - 3 numbers came from (Am Heart Association).  So, until someone comes along to explain better what's going on, I have deleted that phrase and now the sentence reads, "Normal levels increase with aging".--Starlists (talk) 22:23, 25 June 2018 (UTC)

Half life
The "Function" section contains two contradictory sentences:


 * The plasma half-life of CRP is 19 hours.
 * Once inflammation subsides, CRP level falls quickly because of its short half-life (4 to 7 hours).

John Y (talk) 03:13, 9 July 2018 (UTC)


 * I believe the 19 hours estimate is more accurate. The 4 to 7 hours estimates comes from  which in turn cites, and the later two sources state that the half-life of CRP is 19 hours. Hence the 4 to 7 hours estimate appears to be in error. Boghog (talk) 14:46, 1 January 2019 (UTC)

Meaning of 'C' in CRP
First: to all contibuters: great article!

2nd: under "History" the article states that: CRP was so named because it was first identified as a substance in the serum of patients with acute inflammation that reacted with the somatic 'C' carbohydrate antibody of the capsule of pneumococcus.

That may be have so... one day

However, nowadays the 'C' stands for: Capsular-polysaccharide. Is it time to add this point of interest? (since I'm not native speaker I would kindly let the honour to someone who is natively writing)

(ref: M. Levine, Periodontal disease: Section 13.3.1: Long-term Effects of Persistent PAMP Stimulation, In: Topics in Dental Biochemistry, Chapter 13. Published Online by Springer, 2011. See:http://www.springer.com/medicine/dentistry/book/978-3-540-88115-5))

EXCERPT: Activated leukocytes induce the synthesis and secretion from the liver of an unrelated set of proteins called acute-phase proteins. One such protein, C-reactive protein (CRP) was originally identified as binding to the phosphocholine attachment site of capsular polysaccharide (C-polysaccharide) from Streptococcus pneumoniae. CRP in blood has a half life of less than a day, compared with 4 days for fibrinogen. A continuously elevated CRP content indicates a persistent proinflammatory stimulus in the body. CRP binds to host or bacterial phosphocholine, and the complex activates a group of plasma proteins called complement (Sect. 3.3.2). The complement system resembles the blood clotting system, except that proteolytic cleavage of its components results in peptide fragments that to attract and enhance the phagocytosis (opsonization) of CRP- or antibody-bound material by macrophages (like IL-1 or IL-8). CRP is part of the innate immune response, and the antibody response is part of the acquired immune response (Sect. 12.1.4). For further details see also J Immunol. 1984 Sep;133(3):1424-30. PMID: 6747291 NOTE: PAMPs in the Chapter sub-heading are “Pathogen-Associated Molecular Patterns” whose nature and role in activating inflammation is described in section 13.2.1 and section 13.2.2 of the book. Source: https://www.researchgate.net/post/What_does_C_stand_for_in_C-reactive_Protein — Preceding unsigned comment added by Allardo (talk • contribs) 23:34, 15 November 2018 (UTC)


 * Thanks for your note. The two explanations of the origin of the name are not in conflict, but rather than one you found is more detailed. Per your suggestion, I have updated the text in this edit. Boghog (talk) 06:33, 16 November 2018 (UTC)

Depression and elevated CRP
There are a number of reviews and meta-analyses indicating an association of mildly elevated CRP with depression. If nobody speaks out against this, I'll try adding a paragraph summarizing these. Cheers from Yekaterinburg, --CopperKettle (talk) 06:20, 17 June 2023 (UTC)