Talk:C3a (complement)

I made edited this page and sent prospective edits to Immcarle3 in a word documentImmcarle4 (talk) 20:08, 1 March 2016 (UTC)

Useful articles about C3a
For my immunology class, we are editing a relevant stub. Here are a few articles I have looked at so far:

Merle, NS; Noe, R; Halbwachs-Mecarelli, L; Fremeaux-Bacchi, V; Roumenina, LT (2015). "Complement System Part II: Role in Immunity.". Frontiers in immunology 6: 257. .

Strainic, MG; Liu, J; Huang, D; An, F; Lalli, PN; Muqim, N; Shapiro, VS; Dubyak, GR; Heeger, PS; Medof, ME (March 2008). "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.". Immunity 28 (3): 425–35.

Sacks, SH (March 2010). "Complement fragments C3a and C5a: the salt and pepper of the immune response.". European journal of immunology 40 (3): 668–70.

Leslie, JD; Mayor, R (February 2013). "Complement in animal development: unexpected roles of a highly conserved pathway.". Seminars in immunology 25 (1): 39–46.

Lambris, JD; Tsokos, GC (1986). "The biology and pathophysiology of complement receptors.". Anticancer research 6 (3 Pt B): 515–23.

Prospective Lead Section & Changes
C3a is a protein formed by the cleavage of complement component 3. C3a is a 77 residue helix made up of a four-helix bundle fold with a molecular mass of about 10 kDa.

C3a is an anaphylatoxin effector of the complement system with a range of functions including T cell activation and survival, angiogenesis stimulation , and macrophage activation. It has been shown to have both proinflammatory and anti-inflammatory responses, its activity able to counteract the proinflammatory effects of C5a. It has also been shown to regulate monocyte production of IL-1β.

C3a molecules induce responses through the GPCR C3a receptor. Like other anaphylatoxins, C3a is regulated by cleavage of its carboxy-terminal arginine, resulting in C3a desarginine, which possesses lowered biological functions.

Potential Sections:

Structure of C3a

Discuss X-ray structures and 3D structures

Formation of C3a

Regulation of C3a

Talk about regulation by carboxypeptidase B (C3a desArg)

Functions of C3a

Go through a comprehensive list of its functions (immunological and otherwise)